Results 71 to 80 of about 436,604 (311)

Microbiota as Drivers and as Therapeutic Targets in Ocular and Tissue Specific Autoimmunity

Frontiers in Cell and Developmental Biology, 2021
Autoimmune uveitis is a major cause of blindness in humans. Activation of retina-specific autoreactive T cells by commensal microbiota has been shown to trigger uveitis in mice.
Ryan Salvador, Amy Zhang, Reiko Horai, Rachel R. Caspi   +3 more
doaj   +1 more source

Administration of a peptide inhibitor of alpha4-integrin inhibits the development of experimental autoimmune uveitis [PDF]

, 2005
Recruitment of lymphocytes into the retina and to the vitreous during the development of experimental autoimmune uveitis (EAU) is governed by factors such as the state of activation of inflammatory cells and the repertoire of adhesion molecules expressed
Commodaro, Alessandra G., Martín, Andrea P., Rabinovich, Gabriel Adrián, Rizzo, Luiz V., Serra, Horacio Marcelo, Tadokoro, Carlos E., Urrets Zavalia, Enrique, Urrets Zavalía, Julio Alberto, Vieira de Moraes, Luciana   +8 more
core   +1 more source

Induction of antigen-specific Treg cells in treating autoimmune uveitis via bystander suppressive pathways without compromising anti-tumor immunity

EBioMedicine, 2021
Background Induction of autoantigen-specific Treg cells that suppress tissue-specific autoimmunity without compromising beneficial immune responses is the holy-grail for immunotherapy to autoimmune diseases.
Zilin Chen, Tian Zhang, Hiotong Kam, D. Qiao, W. Jin, Yajie Zhong, Minyi Zhou, Hong-yan Zhou, W. Chong, Wanjun Chen, Jun Chen   +10 more
semanticscholar   +1 more source

Prospective study of uveitis in children with juvenile idiopathic arthritis over a 3-year period

Biotechnology & Biotechnological Equipment, 2023
Juvenile idiopathic arthritis (JIA) is the most common systemic autoimmune disease in childhood, which can cause non-infectious uveitis. Ocular inflammation is the most severe, sight-threatening extra-articular complication.
Malina Markova, Stefan Stefanov, Albena Teltcharova-Mihaylovska, Alexander Oscar   +3 more
doaj   +1 more source

Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group. [PDF]

, 2017
Cancer immunotherapy has transformed the treatment of cancer. However, increasing use of immune-based therapies, including the widely used class of agents known as immune checkpoint inhibitors, has exposed a discrete group of immune-related adverse ...
Abdallah, K., Anderson, J., Andrews, S., Arrindell, D., Ballesteros, J., Bingham, C. O., Boyer, J., Brogdon, C., Chen, D., Chonzi, D., Cotarla, I., Cunha, R., Dadu, R., Davies, M., Dawson, M., Diab, A., Dicker, Adam, Eifler, L., Ernstoff, M. S., Ferguson, A., Ferlini, C., Frankel, S., Go, W., Gochett, C., Goldberg, J., Goncalves, P., Goswami, T., Gregory, N., Gulley, J. L., Hamad, L., Hayreh, V., Helie, N., Holmes, W., Hsu, J. Y., Ibrahim, R., Kaufman, H. L., Kim, S., Lacouture, M. E., Lambotte, O., Larocca, C., LeBoeuf, N. R., Lehman, K., Lenihan, D., Ley-Acosta, S., Luke, J., McClure, J., Michelon, E., Nakamura, M., Onofrei, C., Patel, K., Piperdi, B., Puzanov, I., Rasheed, Z., Reshef, D., Riemer, J., Robert, C., Sarkeshik, M., Saylors, A., Schreiber, J., Shafer-Weaver, K., Shannon, V., Sharfman, W., Sharma, R., Sharon, E., Sherry, R., Silk, A. W., Simonson, C., Skondra, D., Suarez-Almazor, M. E., Thomas, C., Thompson, J. A., Trehu, E., Tresnan, D., Turner, M., Wang, Y., Wariabharaj, D., Waxman, I., Wiley, K., Wood, L., Zhang, L., Zheng, P.   +80 more
core   +2 more sources

Deficiency of IL-27 Signaling Exacerbates Experimental Autoimmune Uveitis with Elevated Uveitogenic Th1 and Th17 Responses

International Journal of Molecular Sciences, 2021
Human uveitis is an autoimmune disease of the central nervous system that is characterized by ocular inflammation with the involvement of uveitogenic Th1 and Th17 responses.
Sihan Wu, Rui Ma, Yajie Zhong, Zilin Chen, Hong-yan Zhou, Minyi Zhou, W. Chong, Jun Chen   +7 more
semanticscholar   +1 more source

Immunotherapeutic strategies in autoimmune uveitis

Autoimmunity Reviews, 2014
Autoimmune uveitis is an organ-specific disorder characterized by irreversible lesions to the eye that predominantly affect people in their most productive years and is among the leading causes of visual deficit and blindness. Currently available therapies are effective in the treatment of a wide spectrum of uveitis, but are often associated with ...
Pedro Henrique Papotto, Eliana Blini Marengo, Luiz Roberto Sardinha, Anna Carla Goldberg, Luiz Vicente Rizzo   +4 more
openaire   +2 more sources

Mesenchymal stem cells moderate experimental autoimmune uveitis by dynamic regulating Th17 and Breg cells response

Journal of Tissue Engineering and Regenerative Medicine, 2021
Mesenchymal stem cells (MSCs) are adult stem cells from mesoderm with multi potential differentiation, and are being widely studied as a promising treatment for autoimmune diseases.
Yajun Mu, Wei Xu, Jueling Liu, Yingwei Wang, Jian Chen, Qing Zhou   +5 more
semanticscholar   +1 more source

Mouse Models of Experimental Autoimmune Uveitis [PDF]

Ophthalmic Research, 2008
The mouse model of experimental autoimmune uveitis, induced by immunization of mice with the retinal protein IRBP, was developed in our laboratory 20 years ago and published in 1988. Since that time it has been adopted by many investigators and has given rise to many studies that helped elucidate genetic influences, dissect the basic mechanisms of ...
Rachel R, Caspi, Phyllis B, Silver, Dror, Luger, Jun, Tang, Lizette M, Cortes, Giuseppina, Pennesi, Mary J, Mattapallil, Chi-Chao, Chan   +7 more
openaire   +2 more sources

CRALBP is a Highly Prevalent Autoantigen for Human Autoimmune Uveitis

Clinical and Developmental Immunology, 2007
Cellular retinaldehyde binding protein (CRALBP) is an autoantigen in spontaneous equine recurrent uveitis. In order to test whether CRALBP contributes to human autoimmune uveitis, the specificity of antibodies from human uveitis patient's sera was first ...
Cornelia A. Deeg, Albert J. Raith, Barbara Amann, John W. Crabb, Stephan R. Thurau, Stefanie M. Hauck, Marius Ueffing, Gerhild Wildner, Manfred Stangassinger   +8 more
doaj   +1 more source