Results 21 to 30 of about 199,640 (297)

STIM1 at the plasma membrane as a new target in progressive chronic lymphocytic leukemia

Journal for ImmunoTherapy of Cancer, 2019
Background Dysregulation in calcium (Ca2+) signaling is a hallmark of chronic lymphocytic leukemia (CLL). While the role of the B cell receptor (BCR) Ca2+ pathway has been associated with disease progression, the importance of the newly described ...
Marjolaine Debant, Miguel Burgos, Patrice Hemon, Paul Buscaglia, Tinhinane Fali, Sarra Melayah, Nelig Le Goux, Christophe Vandier, Marie Potier-Cartereau, Jacques-Olivier Pers, Adrian Tempescul, Christian Berthou, Cristina Bagacean, Olivier Mignen, Yves Renaudineau   +14 more
doaj   +1 more source

CD4+-mediated colitis in mice is independent of the GPR183 and GPR18 pathways

Frontiers in Immunology, 2022
Colitis is characterized by an exacerbated intestinal immune response, but the genetic and other mechanisms regulating immune activation remain incompletely understood.
Martina Dicker, Yingcong Li, Yingcong Li, Daniel A. Giles, Greet Verstichel, Viankail Cedillo Castelan, Gabriel Ascui-Gac, Ting-Fang Chou, Tamara Perez-Jeldres, Hilde Cheroutre, Mitchell Kronenberg, Mitchell Kronenberg   +11 more
doaj   +1 more source

Polyubiquitin binding to ABIN1 is required to prevent autoimmunity [PDF]

, 2011
The protein ABIN1 possesses a polyubiquitin-binding domain homologous to that present in nuclear factor kappa B (NF-kappa B) essential modulator (NEMO), a component of the inhibitor of NF-kappa B (I kappa B) kinase (IKK) complex.
Ordureau, Alban, David W. Powell, Rachel Toth, Venigalla, R.K.C., Toth, Rachel, Sambit K. Nanda, J. Simon C. Arthur, Toth, R., Powell, D.W., Venigalla, Ram K. C., Nanda, S.K., C. Arthur, J.S., Janet C. Patterson-Kane, Nanda, Sambit K., Cohen, P., Philip Cohen, Cohen, Philip; id_orcid, Ordureau, A., Arthur, J. Simon C.; id_orcid, Ram K.C. Venigalla, Patterson-Kane, J.C., Alban Ordureau, Patterson-Kane, Janet C., Powell, David W.   +23 more
core   +1 more source

Interleukin-17-producing T helper cells in autoimmunity

, 2022
S.785-792With all the incredible progress in scientific research over the past two decades, the trigger of the majority of autoimmune disorders remains largely elusive.
Sack, Ulrich, Abu El-Saada, Ahmed M., Wichmann, Gunnar, Birkenmeier, Gerd, Conrad, Karsten, Kriegerd, Thorsten, Hemdan, Nasr Y.A.   +6 more
core   +1 more source

Autoimmunity [PDF]

International Journal of Dermatology, 1981
Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/66083/1/j.1365-4362.1981.tb00393.x ...
King, Andrew J., Schwartz, Stanley A., Lopatin, Dennis E., Voorhees, John J., Diaz, Luis A.   +4 more
openaire   +3 more sources

MEK inhibition drives anti-viral defence in RV but not RSV challenged human airway epithelial cells through AKT/p70S6K/4E-BP1 signalling

Cell Communication and Signaling, 2019
Background The airway epithelium is a major target tissue in respiratory infections, and its antiviral response is mainly orchestrated by the interferon regulatory factor-3 (IRF3), which subsequently induces type I (β) and III (λ) interferon (IFN ...
Engin Baturcam, Stefan Vollmer, Holger Schlüter, Rose A. Maciewicz, Nisha Kurian, Outi Vaarala, Stephan Ludwig, Danen Mootoosamy Cunoosamy   +7 more
doaj   +1 more source

dcHiC detects differential compartments across multiple Hi-C datasets

Nature Communications, 2022
The organisation of mammalian genomes plays a role in many biological processes. Here the authors report dcHiC, a tool which uses a multivariate distance measure to identify changes in compartmentalisation among multiple genome-wide chromatin contact ...
Abhijit Chakraborty, Jeffrey G. Wang, Ferhat Ay   +2 more
doaj   +1 more source

Clinical Validity of Anti-Proteinase 3 Antibodies in Patients with Inflammatory Bowel Disease: A Short Meta-Analysis

Diagnostics, 2023
Anti-neutrophil cytoplasmic antibodies (ANCA) directed to proteinase 3 (PR3) represent highly established markers for patients with ANCA-associated vasculitis (AAV). PR3-ANCA have also demonstrated utility in the management of inflammatory bowel disease (
Carmen Andalucía, Laura Martínez-Prat, Chelsea Bentow, Mary Ann Aure, Michael P. Horn, Michael Mahler   +5 more
doaj   +1 more source

Pathogenic mechanisms of IgE-mediated inflammation in self-destructive autoimmune responses

Autoimmunity, 2017
Autoantibodies of the IgG subclass are pathogenic in a number of autoimmune disorders such as systemic lupus erythomatosus. The presence of circulating IgE autoantibodies in autoimmune patients has also been known for almost 40 years.
Rachel Ettinger, Jodi L. Karnell, Jill Henault, Santosh K. Panda, Jeffrey M. Riggs, Roland Kolbeck, Miguel A. Sanjuan   +6 more
doaj   +1 more source

20680 Characterization of Clinical and Immunological Laboratory Features in Multiple Sclerosis Patients with COVID-19

Journal of Clinical and Translational Science, 2021
IMPACT: Better understanding of the factors impacting disease severity and immunological response of MS patients on disease modifying therapy will enable better recommendations for vaccination options and risk mitigation strategies OBJECTIVES/GOALS: The ...
Ahya S Ali, Yang Mao-Draayer
doaj   +1 more source