Results 21 to 30 of about 55,824 (201)

REGULATORY ROLE OF OX22HIGH T-CELLS IN MERCURY-INDUCED AUTOIMMUNITY IN THE BROWN NORWAY RAT [PDF]

, 1993
The monoclonal antibody OX22 defines a functional split within CD4+ T cells in the rat, with OX22high cells mainly producing interleukin 2 (IL-2) and interferon γ and responsible for delayed-type hypersensitivity responses, and OX22low cells mainly ...
P W Mathieson, Oliveira, DBG, Thiru, S, Mathieson, PW, S Thiru, D B Oliveira, Oliveira, DB   +6 more
core   +1 more source

PBMC fixation and processing for Chromium single-cell RNA sequencing

Journal of Translational Medicine, 2018
Background Interest in single-cell transcriptomic analysis is growing rapidly, especially for profiling rare or heterogeneous populations of cells. In almost all reported works investigators have used live cells, which introduces cell stress during ...
Jinguo Chen, Foo Cheung, Rongye Shi, Huizhi Zhou, Wenrui Lu, CHI Consortium   +5 more
doaj   +1 more source

Clinical Factors Associated with Time-Specific Distribution of 18F-Fluorodeoxyglucose in Large-Vessel Vasculitis

Scientific Reports, 2019
18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) can detect vascular inflammation in large-vessel vasculitis (LVV). Clinical factors that influence distribution of FDG into the arterial wall and other tissues have not been characterized in
Joel S. Rosenblum, Kaitlin A. Quinn, Casey A. Rimland, Nehal N. Mehta, Mark A. Ahlman, Peter C. Grayson   +5 more
doaj   +1 more source

Acute cigarette smoke exposure activates apoptotic and inflammatory programs but a second stimulus is required to induce epithelial to mesenchymal transition in COPD epithelium

Respiratory Research, 2017
Background Smoking and aberrant epithelial responses are risk factors for lung cancer as well as chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis.
Lynne A. Murray, Rebecca Dunmore, Ana Camelo, Carla A. Da Silva, Malin J. Gustavsson, David M. Habiel, Tillie L Hackett, Cory M. Hogaboam, Matthew A. Sleeman, Darryl A. Knight   +9 more
doaj   +1 more source

Environmental factors associated with juvenile idiopathic inflammatory myopathy clinical and serologic phenotypes

Pediatric Rheumatology Online Journal, 2022
Background Environmental exposures have been associated with the juvenile idiopathic inflammatory myopathies (JIIM). We undertook a questionnaire-based study to evaluate patient-reported exposures as possible risk factors for JIIM.
Jonathan C. Scalabrini, Adam I. Schiffenbauer, Payam Noroozi Farhadi, Rita Volochayev, Nastaran Bayat, Anna Jansen, Ira N. Targoff, Frederick W. Miller, Lisa G. Rider   +8 more
doaj   +1 more source

Low-Dose Rapamycin Unmasks the Protective Potential of Targeting Intragraft NF-κB for Islet Transplants

Cell Transplantation, 2013
Islet grafts can contribute to their own destruction via the elaboration of proinflammatory genes, many of which are transcriptionally regulated by nuclear factor κ-light-chain-enhancer of activated B-cells (NF-κB).
Nathan W. Zammit, Bernice M. Tan, Stacey N. Walters, David Liuwantara, Jeanette E. Villanueva, Elisabeth K. Malle, Shane T. Grey   +6 more
doaj   +1 more source

CD45 pre-exclusion from the tips of T cell microvilli prior to antigen recognition

Nature Communications, 2021
CD45 limits T cell activation, so its exclusion from the T cell immunological synapse is thought to occur as a means to enable TCR signalling. Here the authors use a variety of cellular imaging methods to show that CD45 is indeed excluded from the tips ...
Yunmin Jung, Lai Wen, Amnon Altman, Klaus Ley   +3 more
doaj   +1 more source

Anti-Carbamylated Protein (Anti-CarP) Antibodies in Patients Evaluated for Suspected Rheumatoid Arthritis

Diagnostics, 2022
(1) Background: Anti-carbamylated protein (CarP) antibodies have been studied as novel markers to aid in the diagnosis and prognosis of rheumatoid arthritis.
Vincent Ricchiuti, Kelly Y. Chun, Jane M. Yang, Mary Ann Aure, Luis Gomez, Gary L. Norman, Michael Mahler   +6 more
doaj   +1 more source

IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE

Nature Communications, 2018
Systemic lupus erythematosus (SLE) is associated with altered B cell responses but the underlying aetiology is still unclear. Here the authors show that a CD11chiT-bet+ B cell subset with a unique phenotype and transcriptome is increased in patients with
Shu Wang, Jingya Wang, Varsha Kumar, Jodi L. Karnell, Brian Naiman, Phillip S. Gross, Saifur Rahman, Kamelia Zerrouki, Richard Hanna, Christopher Morehouse, Nicholas Holoweckyj, Hao Liu, Autoimmunity Molecular Medicine Team, Zerai Manna, Raphaela Goldbach-Mansky, Sarfaraz Hasni, Richard Siegel, Miguel Sanjuan, Katie Streicher, Michael P. Cancro, Roland Kolbeck, Rachel Ettinger   +21 more
doaj   +1 more source

Interaction between extracellular matrix molecules and microbial pathogens: evidence for the missing link in autoimmunity with rheumatoid arthritis as a disease model. [PDF]

, 2014
Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation followed by tissue rebuilding or fibrosis. A failure by the body to regulate inflammation effectively is one of the hallmarks of RA.
Saralili Dipa Robertson, Nidhi eSofat, Robertson, Saralili D, Baines, DL, Wait, R, Robertson, SD, Wait, Robin, Robin eWait, Emma Harriet Baker, Baines, Deborah L, Deborah eBaines, Deborah L. Baines, Sofat, N, Baker, EH, Nidhi Sofat, Saralili D. Robertson, Emma H. Baker, Sofat, Nidhi, Baker, Emma H, Robin Wait   +19 more
core   +1 more source