Results 31 to 40 of about 279,347 (206)
CD45 pre-exclusion from the tips of T cell microvilli prior to antigen recognition
Nature Communications, 2021 CD45 limits T cell activation, so its exclusion from the T cell immunological synapse is thought to occur as a means to enable TCR signalling. Here the authors use a variety of cellular imaging methods to show that CD45 is indeed excluded from the tips ...
Yunmin Jung +3 more
doaj +1 more source
Mucosa-Environment Interactions in the Pathogenesis of Rheumatoid Arthritis [PDF]
, 2019 Mucosal surfaces play a central role in the pathogenesis of rheumatoid arthritis (RA). Several risk factors, such as cigarette smoking, environmental pollution, and periodontitis interact with the host at the mucosal level, triggering immune system ...
Conti, Fabrizio +5 more
core +1 more source
Cell Transplantation, 2013 Islet grafts can contribute to their own destruction via the elaboration of proinflammatory genes, many of which are transcriptionally regulated by nuclear factor κ-light-chain-enhancer of activated B-cells (NF-κB).
Nathan W. Zammit +6 more
doaj +1 more source
Molecular mimicry, genetic homology, and gene sharing proteomic “molecular fingerprints” using an EBV (Epstein-Barr virus)-derived microarray as a potential diagnostic method in autoimmune disease [PDF]
, 2018 EBV (Epstein-Barr Virus) and other human DNA viruses are associated with autoimmune syndromes in epidemiologic studies. In this work, immunoglobulin G response to EBV-encoded proteins which share regions with human immune response proteins from the human
Alessandra Farina, Giuseppina +2 more
core +1 more source
Gastroenterology Report, 2013 Autoimmune pancreatitis (AIP) is a rare, heterogeneous, fibroinflammatory disorder of the pancreas. It has gained increasing recognition due to a presentation that can mimic difficult to treat disorders such as pancreatic cancer, cholangiocarcinoma and primary sclerosing cholangitis. In contrast, autoimmune pancreatitis is a benign disease that is very
Ketwaroo, Gyanprakash A., Sheth, Sunil
openaire +3 more sources
IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE
Nature Communications, 2018 Systemic lupus erythematosus (SLE) is associated with altered B cell responses but the underlying aetiology is still unclear. Here the authors show that a CD11chiT-bet+ B cell subset with a unique phenotype and transcriptome is increased in patients with
Shu Wang +21 more
doaj +1 more source
Molecular Medicine, 2016 The goal of this study was to determine how B-cell-activating factor of the TNF family (BAFF) availability influences selection of the autoreactive B-cell repertoire in NZB/W and NZW/BXSB lupus-prone mice bearing the site-directed heavy-chain transgene ...
Alexis Boneparth +5 more
doaj +1 more source
Nature Communications, 2021 Autoimmunity mediated by age-associated B cells (ABC) can affect males and females differently. Here, using a lupus-like mouse model that affects females more severely, the authors observe an ABC mediated and guanine nucleotide exchange factor (GEF ...
Edd Ricker +14 more
doaj +1 more source
Biomarkers of inflammatory arthritis and proteomics [PDF]
, 2013 N/
FitzGerald, Oliver +3 more
core +3 more sources
Myocardial infarction primes autoreactive T cells through activation of dendritic cells [PDF]
, 2017 Peripheral tolerance is crucial for avoiding activation of self-reactive T cells to tissue-restricted antigens. Sterile tissue injury can break peripheral tolerance, but it is unclear how autoreactive T cells get activated in response to self. An example
Bouché, Ann +14 more
core +12 more sources