Results 21 to 30 of about 4,410 (179)

Pressure and stress transients in autoinjector devices [PDF]

Drug Delivery and Translational Research, 2018
Spring-actuated autoinjectors delivering viscous drug solutions resulting from large drug concentrations require large spring forces which can create high peak pressures and stresses within syringes. The high peak pressures and stresses can lead to device failure.
Jean-Christophe Veilleux, Joseph E. Shepherd   +1 more
openaire   +3 more sources

A 13.2 mg epinephrine intranasal spray demonstrates comparable pharmacokinetics, pharmacodynamics, and safety to a 0.3 mg epinephrine autoinjector

Journal of Allergy and Clinical Immunology: Global
Background: Recent acute anaphylaxis guideline updates have identified remaining unmet needs based on currently available therapeutic options as a critical focus.
David A. Dworaczyk, PhD, Allen L. Hunt, MD, Mike Di Spirito, MSc, Mary Lor, BSc, GrDip, Kenneth L. Dretchen, PhD, Michael J. Lamson, PhD, Jonathan Pollock, MSci, Thelma Ward, PhD   +7 more
doaj   +1 more source

6‐Nitrodopamine as a Novel Mediator of Prostatic Smooth Muscle Function in Mouse and Human

Andrology, EarlyView.
ABSTRACT Background Epithelium‐derived catecholamines contribute to local regulation of genitourinary smooth muscle function, but the role of the endogenous 6‐nitrodopamine (6‐ND) in the prostate remains unknown. Objectives To determine whether 6‐ND is produced by mouse and human prostate and its role in smooth muscle regulation.
Alline Araujo Curiel, Fabio Henrique da Silva, Jéssica Mariana Dias, Luise Gabriela Santos Pereira, Douglas Rafael Martins Dias, Amanda Bueno Olivotti, André Almeida Schenka, Valéria Barbosa de Souza, Masato Tsutsui, Fabiola Zakia Monica, Edson Antunes, Gilberto De Nucci, Mariana G. de Oliveira   +12 more
wiley   +1 more source

Accidental Digital Ischemia by an Epinephrine Autoinjector

Cureus, 2023
Epinephrine is the first line of management of anaphylaxis. Autoinjectors rapidly deliver epinephrine in anaphylaxis in the community. Patients and caregivers have safety concerns regarding their use. Accidental digital injection is a frequently encountered problem that can lead to digital ischemia.
Nayaz, Mohamed, Mohamed, Ahmed, Nawaz, Ali   +2 more
openaire   +2 more sources

User-Centric Approach to Specifying Technical Attributes of Drug Delivery Devices: Empirical Study of Autoinjector-Cap Removal Forces

Patient Preference and Adherence, 2021
Andreas Schneider,1 Philipp Richard,1 Philippe Mueller,1 Christoph Jordi,1 Mary Yovanoff,2 Jakob Lange1 1Ypsomed AG, Burgdorf, Switzerland; 2Design Science, Philadelphia, PA, USACorrespondence: Jakob LangeYpsomed AG, Brunnmattstrasse 6, Burgdorf 3401 ...
Schneider A, Richard P, Mueller P, Jordi C, Yovanoff M, Lange J   +5 more
doaj  

Trends in Cost of Care With Tirzepatide in Adults Aged Over 55 Years With Obesity or Overweight Without Diabetes: A Matched Cohort Analysis

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Compare healthcare cost trends among older adults with obesity or overweight treated with tirzepatide versus no treatment. Materials and Methods Retrospective cohort study using real‐world data from US Komodo Research Dataset, 8 November 2022 to 30 September 2025.
Navneet Upadhyay, Ali Bonakdar, Keshab Subedi, Soutrik Banerjee, Benjamin Behrend, Emily R. Hankosky   +5 more
wiley   +1 more source

Patient Reported Ease-of-Use with a Disposable Autoinjector in Individuals with Migraine

Patient Preference and Adherence, 2020
Jennifer Mead, Ryan Dammerman, Soeren Rasmussen Amgen Inc., Thousand Oaks, CA, USACorrespondence: Jennifer MeadAmgen Inc., One Amgen Center Dr, Thousand Oaks, CA 91320– 1799 Email meadj@amgen.comPurpose: Erenumab-aooe (erenumab, Aimovig®)—
Mead J, Dammerman R, Rasmussen S
doaj  

Preferences for Obesity Medications Among People With Overweight or Obesity in the United States: A Discrete‐Choice Experiment (OPTIC)

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To evaluate the relative importance of attributes driving obesity medication (OM) choice and preferences among individuals with overweight or obesity. Materials and Methods US adults with obesity or overweight and ≥ 1 obesity‐related complication completed an online survey including a discrete‐choice experiment (DCE) in October–November ...
Jaime P. Almandoz, Beverly G. Tchang, Kelley Myers, Andrea Traina, Jigish Bhavsar, Victoria Divino, Cannon Kent, Sara Tadesse Bell   +7 more
wiley   +1 more source

Functionality and Performance of an Accessorized Pre-Filled Syringe and an Autoinjector for At-Home Administration of Tezepelumab in Patients with Severe, Uncontrolled Asthma

Journal of Asthma and Allergy, 2021
Sady Alpizar,1 Ayman Megally,2 Claudia Chen,3 Abhi Raj,4 John Downie,5 Gene Colice2 1Clinical Research Trials of Florida, Inc., Tampa, FL, USA; 2Late-Stage Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD,
Alpizar S, Megally A, Chen C, Raj A, Downie J, Colice G   +5 more
doaj  

Linoleic Acid Enhances Murine Natural Killer Cell Function In Vitro but Compromises Mitochondrial Bioenergetic Function During Retroviral Infection

Immunology, EarlyView.
Natural Killer (NK) cells are potent effectors against virus‐infected and tumour cells. During Friend Virus (FV) infection, fatty acid metabolism supports NK‐cell effector functions. Here, we found that NK cells from FV‐infected mice preferentially take up linoleic acid (LA), which reduced proliferation, mitochondrial function, and increased reactive ...
Vaasudevan Sridhar, Simone Schimmer, Tanja Werner, Rachel Giesen, Mohamed Saad, Constantin P. Krempe, Sven W. Meckelmann, Ulf Dittmer, Elisabeth Littwitz‐Salomon   +8 more
wiley   +1 more source