Results 81 to 90 of about 84,027 (262)

Autologous stem cell transplantation for malignancy: a systematic review of the literature

, 2000
A systematic review of the literature was undertaken to assess what published evidence is currently available to support the increasing use of autologous stem cell transplantation (ASCT), and to evaluate the published data with regard to the comparative ...
Simnett, S.J., Stewart, L. A., Johnson, Peter W.M., Morgan, G., Sweetenham, J.   +4 more
core  

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Autologous hematopoietic stem cell transplantation suppresses Gd-enhanced MRI activity in MS.

, 2001
Background: Autologous hematopoietic stem cell transplantation (ASCT) has been recently utilized with encouraging results in patients with poorly controlled MS.
A. Marmont, the Italian GITMO NEURO Intergroup on Autologous Hematopoietic Stem Cell Transplantation for Multiple Sclerosis, G. L. MANCARDI, TARTARO, Armando, F. GUALANDI, F. Sardanelli, A. MURIALDO, L. MASSACESI, M. P. SORMANI, LUGARESI, Alessandra, FARINA, DEBORAH, M. G. MARROSU, R. SACCARDI, F. PAGLIAI, G. MEUCCI, M. FILIPPI, F. Pagliai, M. P. Sormani, M. INGLESE   +16 more
core   +1 more source

RBC aggregation dynamics in autologous plasma and serum studied with double-channel optical tweezers [PDF]

, 2016
Red blood cells aggregating and disaggregating forces were measured in the autologous plasma and serum using the double-channeled optical tweezers. A significant, three-fold decrease of the both forces was observed in the serum compared to the plasma ...
Potkin, Anton, Priezzhev, Alexander, Lee, Kisung, Meglinski, Igor, Kinnunen, Matti, Danilina, Anna   +5 more
core   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Relapse of Hodgkin lymphoma after autologous transplantation: Time to rethink treatment?

Hematology/Oncology and Stem Cell Therapy, 2017
Relapse of Hodgkin lymphoma after autologous hematopoietic cell transplantation (autologous HCT) is a major therapeutic challenge. Its management, at least in younger patients, traditionally involves salvage chemotherapy aiming to achieve disease ...
Yogesh Jethava, Guru Subramanian Guru Murthy, Mehdi Hamadani   +2 more
doaj   +1 more source

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

In Vivo Emergence of HIV-1 Highly Sensitive to Neutralizing Antibodies [PDF]

, 2011
Background: The rapid and continual viral escape from neutralizing antibodies is well documented in HIV-1 infection. Here we report in vivo emergence of viruses with heightened sensitivity to neutralizing antibodies, sometimes paralleling the development
O'Farrell Stephen, Pellegrino, P, Williams Ian, Williams, IG, Kelly M Cheney, Áine McKnight, Anna Forsman, Cheney, Kelly M, McKnight, Áine, Cheney Kelly M., Hué, Stéphane, Forsman Anna, Marlén M I Aasa-Chapman, McKnight, A, Marlén M. I. Aasa-Chapman, Ian Williams, Aasa-Chapman, Marlén MI, Cheney, KM, O'Farrell, S, Stéphane Hué, Kelly M. Cheney, Pellegrino, Pierre, Stephen O'Farrell, Forsman, A, O'Farrell, Stephen, Pierre Pellegrino, Williams, Ian, Forsman, Anna, Aasa-Chapman Marlén M. I., Aasa-Chapman, MMI, Hué Stéphane, McKnight Áine, Pellegrino Pierre, Williams, I, Hue, S, Aasa-Chapman, MM   +35 more
core   +1 more source

Stem cell transplantation - an overview of clinic-based data and practice in the era of new drugs [PDF]

Vojnosanitetski Pregled
Hematopoietic stem cell transplantation (HSCT) has been the therapy of choice for treating some hematologic malignancies and selected non-malignant disorders for decades.
Todorović-Balint Milena, Vraneš Marija, Pavlović Mirjana, Šerbić Olivera, Pešić Andrej, Lazović Aleksandar, Balint Bela   +6 more
doaj   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source