Results 61 to 70 of about 1,361,764 (281)

Over Half of Patients Progress to Cartilage Restoration After Initial Cartilage Biopsy in a Military Population

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To evaluate the rate of matrix‐induced autologous chondrocyte implantation (MACI) after cartilage biopsy in a military population. Methods A retrospective review was conducted of all patients who underwent a cartilage biopsy at 2 large regional military health centers between January 2021 and May 2023.
Ryan M. Sanborn, Natalia A. Pluta, Kenneth J. Fellows, Christian A. Cruz, Jeanne C. Patzkowski, Daniel J. Cognetti   +5 more
wiley   +1 more source

Cell Therapy in Chagas Disease

Interdisciplinary Perspectives on Infectious Diseases, 2009
Chagas disease which is caused by the parasite Trypanosoma cruzi is an important cause of cardiomyopathy in Latin America. In later stages chagasic cardiomyopathy is associated with congestive heart failure which is often refractory to medical therapy ...
Antonio C. Campos de Carvalho, Regina C. S. Goldenberg, Linda A. Jelicks, Milena B. P. Soares, Ricardo Ribeiro dos Santos, David C. Spray, Herbert B. Tanowitz   +6 more
doaj   +1 more source

The effect of bone marrow microenvironment on the functional properties of the therapeutic bone marrow-derived cells in patients with acute myocardial infarction

Journal of Translational Medicine, 2012
Background Treatment of acute myocardial infarction with stem cell transplantation has achieved beneficial effects in many clinical trials. The bone marrow microenvironment of ST-elevation myocardial infarction (STEMI) patients has never been studied ...
Miettinen Johanna A, Salonen Riikka J, Ylitalo Kari, Niemelä Matti, Kervinen Kari, Säily Marjaana, Koistinen Pirjo, Savolainen Eeva-Riitta, Mäkikallio Timo H, Huikuri Heikki V, Lehenkari Petri   +10 more
doaj   +1 more source

Integrated Clinical and Proteomic Profiling of CD19 Chimeric Antigen Receptor T Cell Therapy in Progressive Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective To characterize the clinical, immunologic, and proteomic changes associated with CD19 chimeric antigen receptor T cell therapy in patients with progressive systemic sclerosis (SSc). Methods Patients with progressive SSc received CD19 chimeric antigen receptor (CAR)‐T cell therapy and were observed longitudinally for safety, clinical efficacy,
Chenhan Jia, Wanyi Lin, Zhangyi Zhao, Fenglin Wu, Chaoyu Gu, Yuankai Sun, Zhe Ding, Chang Wei, Xinyu Li, Cuiwei Xie, Peng Xia, Zhen Xia, Xuesong Liu, Shaoying Yang, Chunyan Zhang, Hanlin Yin, Liangjing Lu   +16 more
wiley   +1 more source

Biological conduits combining bone marrow mesenchymal stem cells and extracellular matrix to treat long-segment sciatic nerve defects

Neural Regeneration Research, 2015
The transplantation of polylactic glycolic acid conduits combining bone marrow mesenchymal stem cells and extracellular matrix gel for the repair of sciatic nerve injury is effective in some respects, but few data comparing the biomechanical factors ...
Yang Wang, Zheng-wei Li, Min Luo, Ya-jun Li, Ke-qiang Zhang   +4 more
doaj   +1 more source

No evidence that FLT3 status should be considered as an indicator for transplantation in acute myeloid leukemia (AML): an analysis of 1135 patients, excluding acute promyelocytic leukemia, from the UK MRC AML 10 and 12 trials [PDF]

, 2005
Fetal liver tyrosine kinase 3 (FLT3) internal tandem duplications (ITDs) are powerful adverse prognostic indicators for relapse in acute myelold leukemia (AML) but the most efficacious therapy for FLT3/ ITD+ patients is currently unknown.
Wheatley, Keith, Burnett, Alan Kenneth, Gale, RE, Hills, Robert Kerrin, Kottaridis, Panagiotis D., Linch, David C., Burnett, AK, Kottaridis, PD, Srirangan, S, Hills, Robert, Hills, R, Srirangan, Sivatharsini, Wheatley, K, Gale, Rosemary E., Linch, DC   +14 more
core   +1 more source

Arthroscopic Treatment of Focal Chondral Defects in the Hip Joint With Autologous Minced Cartilage, Allograft Cartilage Extracellular Matrix, and Platelet‐Rich Plasma

Arthroscopy Techniques, EarlyView.
Abstract Focal chondral defects (FCDs) are often encountered during hip arthroscopy for the treatment of femoroacetabular impingement. Historically, arthroscopic treatment for FCDs in the hip joint has revolved around microfracture, though recent evidence has showed inferior outcomes with this approach. Open cartilage repair procedures in the hip joint
Austin G. Cross, Ashley D. Price, Anthony J. Scillia, Matthew J. Kraeutler   +3 more
wiley   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

Adoptive Immunotherapy in Chimeras with Donor Lymphocytes [PDF]

, 2003
Allogeneic stem cell transplantation has a well-defined indication in the treatment of hematological malignancies. The beneficial immune effect of allogeneic marrow transplantation has long been known, but only recently have methods been developed to ...
Kolb, Hans-Jochem, Roskrow, Marie, Guenther, Wolfgang, Schmid, Christoph, Ledderose, Georg, Weber, Martin, Chen, Xiao, Schleuning, Michael, Woiciechowski, Anja   +8 more
core   +1 more source

Transendocardial injection of expanded autologous CD34+ cells after myocardial infarction: Design of the EXCELLENT trial

ESC Heart Failure, Volume 12, Issue 2, Page 1455-1463, April 2025.
Abstract Aims The extent of irreversible cardiomyocyte necrosis after acute myocardial infarction (AMI) is a major determinant of residual left ventricular (LV) function and clinical outcome. Cell therapy based on CD34+ cells has emerged as an option to help repair the myocardium and to improve outcomes.
Jerome Roncalli, François Roubille, Nicolas Meyer, Giulio Pompilio, Lionel Leroux, Philippe Henon, Guillaume Trebuchet, Anthony Criquet, Matthieu de Kalbermatten, Eric Saloux, Alain Manrique, Pierre‐Yves Marie, Deepak L. Bhatt, Scott D. Solomon, Gilles Montalescot, David E. Newby, Faiez Zannad, on behalf of the EXCELLENT Trial Investigators   +17 more
wiley   +1 more source