Results 21 to 30 of about 149,166 (264)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

A survey of neural architecture search

open access: yesDianxin kexue, 2019
Recently,deep learning has achieved impressive success on various computer vision tasks.The neural architecture is usually a key factor which directly determines the performance of the deep learning algorithm.The automated neural architecture search ...
Mingjie HE, Jie ZHANG, Shiguang SHAN
doaj   +2 more sources

AUTOMATION AND GAMIFICATION OF COMPUTER SCIENCE STUDY

open access: yesStudia Universitatis Babes-Bolyai: Series Informatica, 2019
A large part of the job of a university teacher in computer science is to verify student exercises. The task of verifying correctness, coding style, conventions, and grading is laborious and if done correctly leaves little time for questions. Automating
Imre ZSIGMOND
doaj   +1 more source

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Method for Automated Decomposition of Monolithic Software Systems Based on Graph Neural Networks

open access: yesAxioms
The purpose of this study is to improve the architectural quality of software systems with microservice architecture by investigating and improving methods for automated transition from monolithic architecture to microservice architecture.
Yaroslav Kornaga   +4 more
doaj   +1 more source

A Layered Middleware Architecture for Automated Robot Services

open access: yesInternational Journal of Distributed Sensor Networks, 2014
These days, using robots has gradually been extending from the limited industrial areas in factories to service areas for the general public in everyday life.
Jongsun Choi   +3 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Comparison of manual and semi-automated algorithm for measuring architectural features during different isometric knee extension intensities: a reliability and comparative study in novice raters

open access: yesFrontiers in Rehabilitation Sciences
IntroductionUltrasound is a cost-effective and reliable method to determine skeletal muscle architecture. However, manual analysis of fascicle length (FL) and pennation angle (PA) can be arduous and subjective among raters, particularly among novice ...
Micheal J. Luera   +13 more
doaj   +1 more source

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