Results 51 to 60 of about 119,343 (246)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

ANALYSIS OF ASTUE AT OJSC «BSW – MANAGEMENT COMPANY OF «BMC» HOLDING» ON THE BASIS OF SINIS

open access: yesЛитьë и металлургия, 2013
An automated system of technical calculation of energy resources intended to account for the of power means: delivery water, steam, natural gas, etc. is considered.
S. V. Demyanov
doaj  

Rationale and design of individualized quality improvement based on the Computer Analysing system to improve Stroke management quality Evaluation (CASE): a multicenter historically controlled study

open access: yesTrials, 2020
Background Guideline-based medical care has been identified to improve outcomes in stroke. However, data acquisition and medical quality management during hospital stay still need to be improved in China.
Yi Chen   +8 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Сircuits masks images alignement for automatic optical inspection systems

open access: yesТехнологія та конструювання в електронній апаратурі, 2007
An automated optical positioning system for photomasks of integrated circuits has been developed. The image processing methods are based on hyperbolic wavelet transforms and the calculation of geometric moment features of fiducial marks.
V. N. Krylov   +2 more
doaj  

Automated calculation of complete Pxy and Txy diagrams for binary systems

open access: yesFluid Phase Equilibria, 2007
Abstract An algorithm for the calculation of global phase equilibrium diagrams has been recently developed [M. Cismondi, M.L. Michelsen, Global phase equilibrium calculations: critical lines, critical end points and liquid–liquid–vapour equilibrium in binary mixtures, J. Supercrit. Fluids 39 (2007) 287–295].
Cismondi Duarte, Martín   +1 more
openaire   +2 more sources

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

open access: yesFEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso   +4 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Automation and feedback for hybrid QM/MM calculations of biological systems

open access: yes, 2022
This thesis focuses on the development of new techniques for modelling, parameterising, and analysing fluorescent proteins. Computational studies of fluorescent proteins are plagued by a steep learning curve, external tools demanding differing inputs, and silent errors that go unnoticed for months.
openaire   +2 more sources

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