Results 221 to 230 of about 61,473 (343)

Logic‐Gated HSV‐TK/GCV Suicide Gene Circuit for Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
The BRAS comprises two modular genetic components driven by distinct tumor‐specific promoters and a failsafe layer with the NOT gate. This multi‐input logic gate circuit enables precise, specific expression of HSV‐TK in breast cancer cells with hardly expression in normal cell and effectively inhibits tumor growth in a triple‐negative breast cancer ...
Shasha Tang, Yuan Fang, Lingli Jin, Dongyang Liu, Yicheng Liu, Ruijia Zheng, Liyun Yong, Xin Wu, Longliang Qiao, Meiyan Wang, Fengfeng Cai   +10 more
wiley   +1 more source

Automated manufacturing process for sustainable prototyping of nuclear magnetic resonance transceivers. [PDF]

Magn Reson (Gott)
Wadhwa S, Wang N, Reichert KM, Butzer M, Nassar O, Jouda M, Korvink JG, Gengenbach U, Mager D, Ungerer M.   +9 more
europepmc   +1 more source

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

Multi-AGV path planning method for the textile industry based on improved ant colony optimization algorithm and R-tree line-segment bilayer conflict detection. [PDF]

PLoS One
Xie W, Zheng X, Ma J, Chen J, Du B, Wang X.   +5 more
europepmc   +1 more source

Water‐Efficient Smart Drip Irrigation Enabled by a Low‐Power and High‐Efficiency Flexible Electromagnetic Actuator

Advanced Science, EarlyView.
Water scarcity poses a critical threat to global food security. A low‐power, flexible electromagnetic actuator is presented for smart drip irrigation systems. The device achieves precise, wide‐range flow modulation (0.05–5.8 mL/min) in response to real‐time plant demands, reducing water consumption compared to conventional flood irrigation.
Duo Chen, Xubin Zhu, Minwei Zhang, Kerui Li, Qinghong Zhang, Yaogang Li, Chengyi Hou, Hongzhi Wang   +7 more
wiley   +1 more source

Bridging Genomics and Clinical Medicine: RSVrecon Enhances RSV Surveillance With Automated Genotyping and Clinically Important Mutation Reporting. [PDF]

Influenza Other Respir Viruses
Li L, Yi H, Brazelton JN, Webby RJ, Hayden RT, Wu G, Hijano DR.   +6 more
europepmc   +1 more source

Real‐Time In Vivo Cellular‐Level Imaging During Puncture

Advanced Science, EarlyView.
We present an artificial‐intelligence‐empowered integrative‐light‐field microendoscopy (AIM) needle that delivers real‐time in vivo, diffraction‐limited cellular‐level imaging during puncture and visualizes layered microstructures along the needle path. As a microscopic complement to CT/ultrasound, it improves sampling localization and adds preliminary
Huifang Gao, Jiakang Shao, Quanzhi Li, Yizhou Tan, Liangliang Huang, Xiaorong Xu, Ji Qi, Julin Xiao, Wenwen Li, Zhong Wen, Le Wang, Xu Liu, Qing Yang, Ying Gu   +13 more
wiley   +1 more source

Proceedings: PET Drugs-A 2023 Workshop on Product Quality, Regulatory Submissions, Facility Inspections, and Benefit-Risk Considerations. [PDF]

J Nucl Med
Bunning S, Christodoulou D, Cohen JE, Cutler CS, Dick DW, Ghosh K, Ignace C, Kasliwal RK, Lee H, Marzella L, Pohlhaus T, Scott PJH, Schwarz SW, Syed IA, VanBrocklin HF, Wasil LR, Zigler SS.   +16 more
europepmc   +1 more source

Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines

Advanced Science, EarlyView.
Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira, David Agorku, Andre Rosa, Julia Roosz, Lena Christ, Nicole Anderle, Ajinkya Kulkarni, Abir Hussein, Sana S. Sayedipour, Omar F. Luna, Tobias Legler, Philipp Ströbel, Fernando Albericio, Luis Cruz, Phillipp Beckhove, Peter Loskill, Frauke Alves, M. Andrea Markus, Fernanda Ramos‐Gomes   +18 more
wiley   +1 more source

Origins of chromosome instability unveiled by coupled imaging and genomics. [PDF]

Nature
Cosenza MR, Gaiatto A, Erarslan Uysal B, Andrades Á, Sautter NL, Simunovic M, Jendrusch MA, Zumalave S, Rausch T, Halavatyi A, Geissen EM, Eigenmann JL, Weber T, Hasenfeld P, Benito E, Stober C, Cortes-Ciriano I, Kulozik AE, Pepperkok R, Korbel JO.   +19 more
europepmc   +1 more source