Results 61 to 70 of about 3,652,664 (303)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

An object model development for the UK automated compliance checking [PDF]

, 2013
Approving building designs against existing UK building regulations manually is a time consuming and tedious process. As the architecture engineering construction (AEC) industry moves from 2D CAD drawings to more semantically rich building information ...
Malsane, S., Lockley, Steve, Matthews, Jane, Lockley, S., Malsane, Sagar   +4 more
core  

Adapting Land Use and Infrastructure for Automated Driving: Part A [PDF]

69A3551747105This project is concerned with adapting land use and transportation infrastructure for automated driving. Autonomous vehicles will likely yield a transformation of urban form, its land use and mobility system.
University of Michigan, Ann Arbor, Yin, Yafeng, Center for Connected and Automated Transportation (CCAT)   +2 more
core   +1 more source

Communication Disturbance Observer Based Delay-Tolerant Control for Autonomous Driving Systems

Sensors
With the rapid growth of autonomous vehicle technologies, effective path-tracking control has become a critical component in ensuring safety and efficiency in complex traffic scenarios.
Xincheng Cao, Haochong Chen, Levent Guvenc, Bilin Aksun-Guvenc   +3 more
doaj   +1 more source

Virtual Testing of Automated Driving Systems. A Survey on Validation Methods

IEEE Access, 2022
This paper surveys the state-of-the-art contributions supporting the validation of virtual testing toolchains for Automated Driving System (ADS) verification.
R. Donà, B. Ciuffo
semanticscholar   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Safe Hierarchical Autonomous Driving Framework: Integrating SAC-D Planning With HOCLF-HOCBF-QP Constrained Low-Level Control

IEEE Open Journal of Vehicular Technology
Autonomous driving requires decision-making and motion control algorithms that can ensure both safety and efficiency in complex traffic environments. To address these challenges, this study proposes a hierarchical decision making and control framework ...
Haochong Chen, Bilin Aksun-Guvenc
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Other title: Teen safe driving in Connecticut

, 2014
Annual; "Annual Report on Effectiveness of Connecticut's Teen Driving Laws.

core   +1 more source