Results 41 to 50 of about 18,582,662 (291)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Toward an Automated Learning Control Architecture for Cyber-Physical Manufacturing Systems

IEEE Access, 2022
Manufacturers are constantly looking to enhance the performance of their manufacturing systems by improving their ability to address disruptions and disturbances, while reducing cost and maximizing quantity and quality.
Ilya Kovalenko, James Moyne, Mingjie Bi, EFE C. Balta, Wenyuan Ma, Yassine Qamsane, Xiao Zhu, Z. Morley Mao, Dawn M. Tilbury, Kira Barton   +9 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

A Manufacturing Informatics Framework for Manufacturing Sustainability Assessment. In : Re-engineering Manufacturing for Sustainability, Springer [PDF]

, 2013
Manufacturing firms that wish to improve their environmental performance of their product, process, and systems are faced with a complex task because manufacturing systems are very complex and they come in many forms and life expectancies.
ZHAO, Yaoyao Fiona, ANDRIANKAJA, Héry, PERRY, Nicolas   +2 more
core  

Pressure Control of Electro-Hydraulic Servovalve and Transmission Line Effect

Al-Khawarizmi Engineering Journal, 2013
The effected of the long transmission line (TL) between the actuator and the hydraulic control valve sometimes essentials. The study is concerned with modeling the TL which carries the oil from the electro-hydraulic servovalve to the actuator.
Jafar Mehdi Hassan, Yiqin Xue, Majid Ahmed Oleiwi, Ahmed Fouad Mahdi   +3 more
doaj  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Robust Supervisory Control for Automated Manufacturing Systems With Minimal Decentralized Switch-Buffer Controllers

IEEE Access
Automated manufacturing systems require effective supervisory control mechanisms to ensure their efficient operation and prevent fatal errors. Majority of the deadlock supervisory control policies for automated manufacturing systems are formulated based ...
Umar Suleiman Abubakar, Ahmad Bala Alhassan, Gridsada Phanomchoeng   +2 more
doaj   +1 more source

Automated derivation of variants in manufacturing systems design

Proceedings of the 25th ACM International Systems and Software Product Line Conference - Volume B, 2021
The Logistics Specification and Analysis Tool (LSAT) is a modelbased engineering tool used for design-space exploration of flexible manufacturing systems. LSAT provides domain specific languages to model a manufacturing system and means to analyze the productivity characteristics of such a system.
Kahraman, Gökhan, Cleophas, Loek
openaire   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source