Results 31 to 40 of about 3,868,631 (298)

Automated Discrimination of Pathological Regions in Tissue Images: Unsupervised Clustering vs Supervised SVM Classification [PDF]

, 2008
Recognizing and isolating cancerous cells from non pathological tissue areas (e.g. connective stroma) is crucial for fast and objective immunohistochemical analysis of tissue images.
Enrico Macii, Elisa Ficarra, Santa Di Cataldo, Ficarra, Elisa, Di Cataldo, Santa, Macii, Enrico   +5 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Automated camera ranking and selection using video content and scene context [PDF]

, 2012
PhDWhen observing a scene with multiple cameras, an important problem to solve is to automatically identify “what camera feed should be shown and when?” The answer to this question is of interest for a number of applications and scenarios ranging from ...
Daniyal, Fahad M.
core   +2 more sources

Artifact Removal in Electrocorticography Devices With Cardiac Contamination

IEEE Transactions on Neural Systems and Rehabilitation Engineering
Electrocorticography (ECoG) devices with electronics housed near the chest are susceptible to artifacts of a differing nature to electroencephalography (EEG) and standard ECoG.
K. A. Liyanage, P. E. Yoo, D. B. Grayden, N. L. Opie, T. J. Oxley   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Automated seamless DNA co-transformation cloning with direct expression vectors applying positive or negative insert selection

BMC Biotechnology, 2010
Background Molecular DNA cloning is crucial to many experiments and with the trend to higher throughput of modern approaches automated techniques are urgently required.
Frey Daniel, Edmondson Sonia, Crone Stephanie, Sauter Marion, Wagen Sandro, Kuchen Melanie, Olieric Natacha, Ostermeier Christian, Steinmetz Michel O, Jaussi Rolf   +9 more
doaj   +1 more source

Automated Selection of Active Orbital Spaces [PDF]

Journal of Chemical Theory and Computation, 2016
29 pages, 10 figures, 5 ...
Stein Christopher J., Reiher Markus
openaire   +4 more sources

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Automated Oracle Data Selection Support [PDF]

IEEE Transactions on Software Engineering, 2015
The choice of test oracle—the artifact that determines whether an application under test executes correctly—can significantly impact the effectiveness of the testing process. However, despite the prevalence of tools that support test input selection, little work exists for supporting oracle creation.
Gregory Gay 0002, Matt Staats, Michael W. Whalen, Mats Per Erik Heimdahl   +3 more
openaire   +2 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source