Results 71 to 80 of about 157,751 (260)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

The impact of automated writing evaluation (AWE) on EFL learners' peer and self-editing. [PDF]

Educ Inf Technol (Dordr), 2023
Al-Inbari FAY, Al-Wasy BQM.
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Elucidating university students’ intentions to seek automated writing feedback from Grammarly: toward perceptual and systemic predictors

Humanities & Social Sciences Communications
Automated writing evaluation has gained popularity in technology-enhanced language education, while learners’ technology acceptance of such tools has yet to be thoroughly investigated.
Yupeng Lin, Zhonggen Yu
doaj   +1 more source

Transformer-LSTM Models for Automatic Scoring and Feedback in English Writing Assessment

IEEE Access
Writing assessment is one of the most important stages in the educational process, but it is also the most resource-demanding one. To address the challenges of scalability and inconsistency, this study proposes a Transformer-LSTM model for automated ...
Yunyun Xuan
doaj   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

A Latent Dirichlet Allocation approach to understanding students’ perceptions of Automated Writing Evaluation

Computers and Education Open
Automated writing evaluation (AWE) has shown promise in enhancing students’ writing outcomes. However, further research is needed to understand how AWE is perceived by middle school students in the United States, as they have received less attention in ...
Joshua Wilson, Saimou Zhang, Corey Palermo, Tania Cruz Cordero, Fan Zhang, Matthew C. Myers, Andrew Potter, Halley Eacker, Jessica Coles   +8 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Developing and validating an online module for formative assessment of summary writing with automated content feedback for EFL academic writing instruction

Language Testing in Asia
The present paper provides an overview of an online module for formative assessment of summary writing skills for second language (L2) introductory academic writing instruction in Japan and presents initial empirical results on how Japanese undergraduate
Yasuyo Sawaki, Yutaka Ishii, Hiroaki Yamada, Takenobu Tokunaga   +3 more
doaj   +1 more source