Results 51 to 60 of about 531,664 (266)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Discriminative and Graph Regularized Nonnegative Matrix Factorization with Kernel Method
Jisuanji kexue yu tansuo, 2020 Nonnegative matrix factorization (NMF) is a popular technique for dimension reduction,which has been extensively applied in image clustering and other fields.However,NMF is an unsupervised approach,which does not take the label information of the data ...
LI Xiangli, ZHANG Ying
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Oriental Studies, 2018 The article describes the grammar of orders of inflectional affixes of finite verb forms in the indirect moods of the Kalmyk language. The relevance of the research is determined by the need of classification and systematic descriptive analysis of the ...
V. .. Kukanova
doaj
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
State Filtering for Networked Control Systems Subject to Switching Disturbances
International Journal of Applied Mathematics and Computer Science, 2018 State estimation of stochastic discrete-time linear systems subject to unknown inputs has been widely studied, but few works take into account disturbances switching between unknown inputs and constant biases.
Chabir Karim +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
A Variable Structure Control Scheme Proposal for the Tokamak à Configuration Variable
Complexity, 2019 Fusion power is the most significant prospects in the long-term future of energy in the sense that it composes a potentially clean, cheap, and unlimited power source that would substitute the widespread traditional nonrenewable energies, reducing the ...
Aitor Marco +4 more
doaj +1 more source
AScall – Automatic Allele-Specific qPCR Analysis
Frontiers in Bioengineering and Biotechnology, 2020 Minor histocompatibility antigens (MiHA) are critical elements for the immune response after allogeneic hematopoietic stem cell transplantation. They may cause both beneficial and detrimental effects in forms of graft-versus-tumor and graft-versus-host ...
Konstantin Blagodatskikh +2 more
doaj +1 more source