Results 81 to 90 of about 2,190,498 (300)

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

The microbiome biomarkers of pregnant women’s vaginal area predict preterm prelabor rupture in Western China

Frontiers in Cellular and Infection Microbiology
IntroductionIntraamniotic infection is crucial in preterm prelabor rupture of membranes(PPROM), a clinical condition resulting from the invasion of vaginal opportunistic microbes into the amniotic cavity.
Yuanting Tang, Yuanting Tang, Xia Wang, Xia Wang, Jialing Huang, Jialing Huang, Jialing Huang, Yongmei Jiang, Yongmei Jiang, Fan Yu, Fan Yu   +10 more
doaj   +1 more source

A primal-dual algorithm framework for convex saddle-point optimization

Journal of Inequalities and Applications, 2017
In this study, we introduce a primal-dual prediction-correction algorithm framework for convex optimization problems with known saddle-point structure. Our unified frame adds the proximal term with a positive definite weighting matrix.
Benxin Zhang, Zhibin Zhu
doaj   +1 more source

Automatic Loop Kernel Analysis and Performance Modeling With Kerncraft

, 2015
Analytic performance models are essential for understanding the performance characteristics of loop kernels, which consume a major part of CPU cycles in computational science.
Eitzinger, Jan, Hager, Georg, Hammer, Julian, Wellein, Gerhard   +3 more
core   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

MAGiC: A multimodal framework for analysing gaze in dyadic communication

Journal of Eye Movement Research, 2018
The analysis of dynamic scenes has been a challenging domain in eye tracking research. This study presents a framework, named MAGiC, for analyzing gaze contact and gaze aversion in face-to-face communication. MAGiC provides an environment that is able to
Ülkü Arslan Aydin, Sinan Kalkan, Cengiz Acarturk   +2 more
doaj   +1 more source

Automatic analysis of Swift-XRT data

, 2007
The Swift spacecraft detects and autonomously observes ~100 Gamma Ray Bursts (GRBs) per year, ~96% of which are detected by the X-ray telescope (XRT). GRBs are accompanied by optical transients and the field of ground-based follow-up of GRBs has expanded
Beardmore, A. P., Evans, P. A., Osborne, J. P., Tyler, L. G.   +3 more
core  

Challenges in the Automatic Analysis of Students' Diagnostic Reasoning

, 2018
Diagnostic reasoning is a key component of many professions. To improve students' diagnostic reasoning skills, educational psychologists analyse and give feedback on epistemic activities used by these students while diagnosing, in particular, hypothesis ...
Bauer, Elisabeth, Fischer, Frank, Fischer, Martin R., Gurevych, Iryna, Kiesewetter, Jan, Meyer, Christian M., Sailer, Michael, Schulz, Claudia   +7 more
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source