Results 41 to 50 of about 1,091,165 (230)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Model for Automatic Image Annotation Leveraging the OnTunAr Ontology

Computing Open
In this paper, we present the Automatic Annotation of Archaeological Images model. However, this model is composed of several methods for the analysis, description, and recognition of image components to improve the automatic annotation. Also, the latter
Marwa Ben Salah, Ameni Yengui, Mahmoud Neji   +2 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Semi-Automatic Framework for Traffic Landmark Annotation

IEEE Open Journal of Intelligent Transportation Systems, 2021
We present a semi-automatic annotation method to build a large dataset for traffic landmark detection, where traffic landmarks include traffic signs, traffic lights as well as road markings.
Won Hee Lee, Kyungboo Jung, Chulwoo Kang, Hyun Sung Chang   +3 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Semi-automatic conversion of BioProp semantic annotation to PASBio annotation

BMC Bioinformatics, 2008
Background Semantic role labeling (SRL) is an important text analysis technique. In SRL, sentences are represented by one or more predicate-argument structures (PAS).
Dai Hong-Jie, Tsai Richard, Huang Chi-Hsin, Hsu Wen-Lian   +3 more
doaj   +1 more source

Visual attention mechanism and support vector machine based automatic image annotation. [PDF]

PLoS ONE, 2018
Automatic image annotation not only has the efficiency of text-based image retrieval but also achieves the accuracy of content-based image retrieval. Users of annotated images can locate images they want to search by providing keywords.
Zhangang Hao, Hongwei Ge, Long Wang
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Automatic Ontology-Based Knowledge Extraction from Web Documents [PDF]

, 2003
To bring the Semantic Web to life and provide advanced knowledge services, we need efficient ways to access and extract knowledge from Web documents. Although Web page annotations could facilitate such knowledge gathering, annotations are rare and will ...
Hall, Wendy, Shadbolt, Nigel R., Alani, Harith, Weal, Mark J., Kim, Sanghee, Lewis, Paul H., Millard, David E.   +6 more
core   +2 more sources