Results 51 to 60 of about 12,871,614 (301)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Enhancing Grid Operation with Electric Vehicle Integration in Automatic Generation Control

open access: yesEnergies, 2023
Wind energy has been recognized as a clean energy source with significant potential for reducing carbon emissions. However, its inherent variability poses substantial challenges for power system operators due to its unpredictable nature.
Zahid Ullah   +4 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

Optimal design of PD-Fuzzy-PID cascaded controller for automatic generation control

open access: yesCogent Engineering, 2017
In this research paper a novel cascaded PD-Fuzzy-PID controller is recommended for a conventional hybrid-source unified power system for automatic generation control. The optimization of scaling parameters of the suggested PD-Fuzzy-PID controller is done
Manoj Kumar Debnath   +2 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

Asynchronous motor control using an automatic code generation tool

open access: yes, 2023
This thesis deals with the control of an asynchronous motor in MATLAB/Simulink using the automatic code generation tool in C. The aim of the thesis is to learn about the theory of asynchronous motor control, the programming and simulation tool X2C and ...
Jochec, Jan
core   +1 more source

Designing Structure-Dependent MPC-Based AGC Schemes Considering Network Topology

open access: yesEnergies, 2015
This paper presents the important features of structure-dependent model predictive control (MPC)-based approaches for automatic generation control (AGC) considering network topology. Since power systems have various generators under different topologies,
Young-Sik Jang   +2 more
doaj   +1 more source

Friction Coefficient Influence on the Engagement Uncertainty in Dry-Clutch AMT

open access: yes, 2016
This paper focuses on the control of automotive gearbox based on dry-clutch architecture. Such a system is widely spread as engagement device in Automated Manual Transmissions (AMTs) and Dual-Clutch Transmissions (DCT) to manage the energy flow from the ...
Mario Pisaturo   +5 more
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

open access: yesMolecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David   +12 more
wiley   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

open access: yesMolecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan   +8 more
wiley   +1 more source

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