Results 61 to 70 of about 803,126 (302)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Reconfiguration based built-in self-test for analogue front-end circuits [PDF]

open access: yes, 1999
Previous work has shown that it is feasible to implement a fully digital test evaluation function to realise partial self-test on an automatic gain control circuit (AGC).
Hermes, B.   +2 more
core  

Computational Particle Physics for Event Generators and Data Analysis

open access: yes, 2012
High-energy physics data analysis relies heavily on the comparison between experimental and simulated data as stressed lately by the Higgs search at LHC and the recent identification of a Higgs-like new boson.
Perret-Gallix, Denis
core   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Machine learning surrogates for CALPHAD inputs in mean-field precipitation modelling of IN738LC

open access: yesMaterials & Design
This study presents a novel application of a machine learning-based surrogate modelling approach to replace CALPHAD-based inputs in the mean-field simulation of γ′ precipitation in the nickel-based superalloy IN738LC.
Z.Y. Cao   +4 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Designing Structure-Dependent MPC-Based AGC Schemes Considering Network Topology

open access: yesEnergies, 2015
This paper presents the important features of structure-dependent model predictive control (MPC)-based approaches for automatic generation control (AGC) considering network topology. Since power systems have various generators under different topologies,
Young-Sik Jang   +2 more
doaj   +1 more source

Less is More: Real-time Failure Localization in Power Systems [PDF]

open access: yes, 2019
Cascading failures in power systems exhibit non-local propagation patterns which make the analysis and mitigation of failures difficult. In this work, we propose a distributed control framework inspired by the recently proposed concepts of unified ...
Guo, Linqi   +4 more
core   +4 more sources

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

open access: yesFEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth   +6 more
wiley   +1 more source

PLC design for automatic power transfer of 11kv switchgear [PDF]

open access: yes, 2022
An Automated Transfer System (ATS) is to provide automatic power transfers to groups reloading loads from common sources, such as utility services, to alternative sources, such as standby generation, in the event of a normal source failure.
Abdul Wahab, Yasmin   +6 more
core  

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