Directed evolution of enzymes at the crossroads of tradition and innovation
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Fully distributed optimal automatic generation control for an islanded microgrids
Microgrids (MGs) have been receiving more and more attention, as it can environmentally and reliably integrate intermittent renewable energy sources (RES).
Bian J(卞晶) +4 more
core
Software and hardware platform for testing of Automatic Generation Control algorithms
Development and implementation of new Automatic Generation Control (AGC) algorithms requires testing them on a model that adequately simulates primary energetic, information and control processes.
Vasiliev Alexey +2 more
doaj +1 more source
A hybrid chemical reaction-particle swarm optimisation technique for automatic generation control
In this paper, a novel hybrid chemical reaction optimisation and particle swarm optimisation (HCROPSO) optimised PI controller has been proposed for automatic generation control (AGC) problem.
Banaja Mohanty, P.K. Hota
doaj +1 more source
Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
wiley +1 more source
Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall +16 more
wiley +1 more source
Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis
ABSTRACT Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron‐laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on PRLs remains unclear. In a longitudinal study of 29 ocrelizumab‐treated patients with at least
Kimberly H. Markowitz +9 more
wiley +1 more source
Model based code generation for distributed embedded systems [PDF]
Embedded systems are becoming increasingly complex and more distributed. Cost and quality requirements necessitate reuse of the functional software components for multiple deployment architectures.
Gopalswamy, Swaminathan +4 more
core
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen +7 more
wiley +1 more source
Agent-based distributed and economic automatic generation control for droop-controlled AC microgrids
Microgrids (MGs) are presented as a cornerstone of smart grid, which can integrate renewable energy sources environmentally, friendly, and reliably. Hierarchical control strategies, i.e.
Li ZW(李忠文) +4 more
core

