Results 51 to 60 of about 6,814 (202)

GPX4 Inhibitor Resistance and Metastatic Features in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study establishes breast cancer cell lines that are resistant to glutathione peroxidase 4 inhibitors (GPX4i) in vitro and investigates the metastatic capacity of the GPX4i‐resistant versus parental lines in vivo. GPX4i‐resistant cells survive upon intravenous injection, but lose capacity to spontaneously metastasize.
Marie Sabatier, Mayher Kaur, Milena Chaufan, Felix‐Levin Hormann, Luiza Martins Nascentes Melo, Mario Palma, Jordan Torpey, Yanshan Liang, Alanis Carmona, Cameron Fraser, Midori Flores, Krystina J. Szylo, Mahsa Yavari, Sheng Hui, Alpaslan Tasdogan, Sven Heiles, Jessalyn M. Ubellacker   +16 more
wiley   +1 more source

Optimal Array Reconfiguration of a PV Power Plant for Frequency Regulation of Power Systems

Frontiers in Energy Research, 2021
This paper establishes a novel optimal array reconfiguration (OAR) of a PV power plant for secondary frequency control of automatic generation control (AGC).
Tingyi He, Shengnan Li, Yiping Chen, Shuijun Wu, Chuangzhi Li   +4 more
doaj   +1 more source

Programmable RNA N6,2´‐O‐Dimethyladenosine Editing

Advanced Science, EarlyView.
ABSTRACT N6,2’‐O‐dimethyladenosine (m6Am) is a prevalent RNA modification located at the first transcribed nucleotide adjacent to the 5′ cap of mRNAs, where it has been implicated in gene regulation. However, the lack of methods for precise, transcript‐specific manipulation of m6Am has limited its functional dissection.
Yang Li, Xiangmin Tan, Yaran Liu, Yongquan He, Bo Yuan, Ping Wang, Guangzhi Ma, Mengzhe Guo, Jian Zhou, Qiang Sun   +9 more
wiley   +1 more source

Plasma Proteomics Identifies Thousand‐and‐One–Amino Acid Kinase 3 as a Potential Biomarker of Rheumatoid Arthritis Activity and a Novel Therapeutic Target

Arthritis &Rheumatology, EarlyView.
Objective Bone destruction associated with active rheumatoid arthritis (RA) remains a major therapeutic challenge, with a lack of reliable molecular markers reflecting bone injury. This study aims to identify novel biomarkers linked to bone destruction in active RA through proteomic analysis, providing new strategies for precise monitoring and targeted
Pengfei Xin, Wenzhen Li, Xinyu A, Jun Shen, Xiaohui Meng, Yanqin Bian, Haihui Han, Zheng Xiang, Lei Ran, Songtao Sun, Jun Xie, Tao Yue, Qi Zhu, Xiaoming Zhang, Lu Xie, Lianbo Xiao   +15 more
wiley   +1 more source

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg, Tanja M. Gampfer, Lea Wagmann, Philip Schippers, Jennifer Herrmann, Rolf Müller, Folker Westphal, Markus R. Meyer   +7 more
wiley   +1 more source

Cost-Effective automatic generation control for Renewable-dominated grids: Multi-Agent deep reinforcement learning approach

International Journal of Electrical Power & Energy Systems
As power systems continue to increase in complexity, real-time frequency control has become progressively more critical for balancing power supply and demand by modulating generating unit outputs.
Yoongun Jung, Sungwoo Kang, Junsang Cha, Sungyoon Song, Minhan Yoon, Gilsoo Jang   +5 more
doaj   +1 more source

Polyvinylidene Fluoride: A Growing Specialty Polymer with Many Facets

Chinese Journal of Chemistry, EarlyView.
Comprehensive Summary Polyvinylidene fluoride (PVDF), the second largest produced fluoropolymer, exhibits outstanding chemical, physical, electroactive and electrochemical properties and is involved in many High‐Tech applications. This review reports recent novelties in synthesis, characterization, processes and applications. Recent preparation studies
Bruno Améduri
wiley   +1 more source

On the Contribution of Wind Farms in Automatic Generation Control: Review and New Control Approach

Applied Sciences, 2018
Wind farms can contribute to ancillary services to the power system, by advancing and adopting new control techniques in existing, and also in new, wind turbine generator systems.
Arman Oshnoei, Rahmat Khezri, SM Muyeen, Frede Blaabjerg   +3 more
doaj   +1 more source

Two‐Layer Optimal Control Strategy of Thermal Power Unit Coupled With Hybrid Energy Storage System in Frequency Regulation

Energy Science &Engineering, EarlyView.
An optimized two‐layer TPU‐HESS operation strategy enables adaptive power allocation, mitigates regulation delay, and enhances AGC performance by 6.4% over conventional control methods. ABSTRACT With the growing penetration of renewable energy, its intermittency and fluctuation have imposed increasingly stringent regulation requirements on thermal ...
Zhiwei Xing, Lu Liang, Yunfeng Tian, Lei Liu, Chuan Zuo, Longfei Zhu, Zhan Li, Zhenyong Yang, Jingqiu Kang, Feng Hong   +9 more
wiley   +1 more source

Dynamic Optimization Model of AGC Units Considering TCPS Assessment Constraints

Zhongguo dianli
In recent years, power grid has begun to use the transformational control performance standard (TCPS) to assess the level of automatic generation control (AGC) in various regions.
Sheng CHEN, Honglue ZHANG, Tian XIA, Xue YANG, Wenjun ZHANG, Wei YAN   +5 more
doaj   +1 more source