Results 51 to 60 of about 1,010 (193)

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

open access: yesAdvanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang   +6 more
wiley   +1 more source

Chance constrained dynamic optimisation method for AGC units dispatch considering uncertainties of the offshore wind farm

open access: yesThe Journal of Engineering, 2019
The continuing growth of an offshore wind farm integrated into a power grid via high-voltage DC has posed great challenges for automatic generation control (AGC) of the power system.
Xia Zhao   +4 more
doaj   +1 more source

MiR‐940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes

open access: yesAdvanced Science, EarlyView.
A CRISPR‐based screening identified miR‐940 as a critical suppressor of ferroptosis in cancer. By coordinating the downregulation of pro‐ferroptotic genes with the upregulation of GPX4, miR‐940 establishes a regulatory network that protects against ferroptosis and correlates with poor clinical outcomes in distinct cancer entities.
Andrea Kolak   +19 more
wiley   +1 more source

Research on Optimal Distributed Control System of Active Power of Wind Turbine Generators

open access: yes发电技术, 2018
In this paper, an optimal distributed control strategy of active power of wind turbine generators was proposed. Based on this strategy, a development scheme of optimal distributed control system was proposed.
Zhongquan ZHANG   +2 more
doaj   +1 more source

Innovations in Gastric Cancer Surgery During Early Minimally Invasive Era and Future Perspectives

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
With continuing revelations in tumor biology and the emergence of artificial intelligence, new horizons for surgical innovation are opening. At the center of this transformative journey stands the innovative surgeon, driven by passion, guided by data, and steadfast in the commitment to patient safety and quality of life.
Reut El‐On, Young‐Woo Kim
wiley   +1 more source

Study on AGC strategy involving the frequency control of HVDC power regulation

open access: yesEnergy Reports, 2022
The asynchronous interconnection between the Southwest China power grid (SCPG) and Central China power grid (CCPG) reduces the inertia of rotation of SCPG to 1/5, which leads to a prominent risk of frequency stability.
Gang Chen   +5 more
doaj   +1 more source

Pylorus‐Preserving Gastrectomy for Gastric Cancer: Current Evidence and Future Directions

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
This review aims to outline the current evidence and future directions of PPG, focusing on the feasibility of extending its application beyond its traditional indications. ABSTRACT Pylorus‐preserving gastrectomy (PPG) is a function‐preserving surgery for clinically T1N0M0 (cT1N0M0) early gastric cancer (EGC) located in the middle third of the stomach ...
Sa‐Hong Kim, Hyuk‐Joon Lee
wiley   +1 more source

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg   +7 more
wiley   +1 more source

Exercise‐specific plasma proteomic signatures in racehorses: Candidates for training adaptation and peak load monitoring

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka   +4 more
wiley   +1 more source

Flexible Automatic Generation Control system for embedded HVDC links [PDF]

open access: yes, 2015
Frequency quality will be maintained as ancillary service instead of utilities, and different qualities in one system may be requested depends on the framework of service.
Anton Steliuk (7209971)   +5 more
core   +1 more source

Home - About - Disclaimer - Privacy