Results 91 to 100 of about 70,289 (311)

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Automatic Target Recognition from an Engineering Perspective

, 2022
Automatic Target Recognition (ATR) is a special engineering application field which is closely related to signal and information processing, pattern recognition, artificial intelligence and other disciplines.
Wenxian YU
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Airborne behaviour monitoring using Gaussian processes with map information [PDF]

, 2013
This paper proposes an airborne behaviour monitoring methodology of ground vehicles based on a statistical learning approach with domain knowledge given by road map information.
Shin, Hyosang, Seungkeun Kim (7121504), Hyo-Sang Shin (7121507), Antonios Tsourdos (7121918), Oh, Hyondong, Tsourdos, Antonios, Kim, Seungkeun, Hd Oh (1252035), Shin, Hyo-Sang, White, Brian A, Barry A. White (7122041), White, Brian A.   +11 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Adaptive PHD-BOF: A Slow-moving Targets Tracking Method with Air Surveillance Radar

Leida xuebao
Low-altitude targets, represented by rotor unmanned aerial vehicles, can typically adopt a slow-cruise mode. As a result, their echoes fall within the Doppler Blind Zone (DBZ) and evade radar detection and tracking. The cluttered low-altitude environment
Yingjian ZHAO, Libing JIANG, Shuyu ZHENG, Qingwei YANG, Zhuang WANG   +4 more
doaj   +1 more source

Joint Tracking and Classification of Extended Targets Using Random Matrix and Bernoulli Filter for Time-Varying Scenarios

IEEE Access, 2019
In surveillance applications, the extent states and measurements of extended targets received by sensors are time-varying. In this paper, we propose a joint tracking and classification (JTC) method for single extended target under the presence of clutter
Liping Wang, Yuan Huang, Ronghui Zhan, Jun Zhang   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Exploiting Multi-View SAR Images for Robust Target Recognition

Remote Sensing, 2017
The exploitation of multi-view synthetic aperture radar (SAR) images can effectively improve the performance of target recognition. However, due to the various extended operating conditions (EOCs) in practical applications, some of the collected views ...
Baiyuan Ding, Gongjian Wen
doaj   +1 more source