Results 21 to 30 of about 83,494 (318)

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Research and Analysis of Traffic Intensity on a Street with High Traffic Load: Case Study of the City of Sofia

Engineering Proceedings
The study of traffic parameters in cities is the basis for making adequate decisions related to the organization and regulation of traffic. This publication presents a study of one of the main parameters of transport flows, namely, its intensity.
Durhan Saliev, Georgi Mladenov, Plamen Petkov   +2 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Concept as a stage of designing and evaluating car consumer properties

Вестник университета
The role of concept cars in designing and evaluating car consumer properties, such as interior and exterior design, functional features, and positioning, has been considered.
D. F. Karimov
doaj   +1 more source

Estimation of Engine Intake Air Mass Flow using a generic Speed-Density method

Journal of Middle European Construction and Design of Cars, 2014
Measurement of real driving emissions (RDE) from internal combustion engines under real-world operation using portable, onboard monitoring systems (PEMS) is becoming an increasingly important tool aiding the assessment of the effects of new fuels and ...
Vojtíšek Michal, Kotek Martin
doaj   +1 more source

Восстановление тонкостенных деталей автомобильных двигателей [PDF]

, 2011
Restoration of thin-walled parts of automobile engines Yaroshevich VKПредложены способы восстановления тонкостенных деталей автомобильных ...
Ярошевич, В. К.
core   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Parameters Characterizing the Performance of Automotive Electronic Control Systems on Petrol Engine Emissions

Engineering Proceedings
It is evident that a novel engineering solution is required in order to elevate a greater number of polluting cars into a higher category. There appears to be a paucity of direct interest in upgrading Euro 1, 2, 3, 4, and 5 vehicles to the highest ...
Hristo Konakchiev, Evgeni Dimitrov
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Interaction between Molten Al‐Killed Mn–B Steel and Carbon‐Bonded MgO Refractories Based on Recyclates

Advanced Engineering Materials, EarlyView.
High‐temperature interactions between low‐sulfur Al‐killed Mn–B steel and MgO–C refractories (0 and 50 wt% recyclates) are studied via finger immersion tests (1600 °C). Surface‐active elements influence infiltration. MgO/CaS layer forms, along with spinel and calcium silicate.
Matheus Roberto Bellé, Lukas Neubert, Anton Yehorov, Till M. J. Stadtmüller, Christos G. Aneziris, Olena Volkova   +5 more
wiley   +1 more source