Results 31 to 40 of about 358,824 (288)

Effect of fullerene-like nanoparticles at low concentrations on the anti-wear properties of motor fuels

open access: yesПроблеми трибології, 2022
Motor fuels are the source of energy for internal combustion engines, and also a lubricant for friction units of the fuel equipment of automobile, aircraft and ship engines.
V.S. Pyliavsky   +3 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

open access: yesMolecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Influence of Engine Load on Soot Mass Concentration and Morphology in Diesel Exhaust

open access: yesAtmosphere
This study investigates the relationship between exhaust gas composition, particle number (PN) emissions, and soot microstructure of a 1.9 L compression-ignition engine operated under six controlled steady-state load regimes at 2000 min−1.
Iliyan Damyanov   +3 more
doaj   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

open access: yesFEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson   +2 more
wiley   +1 more source

Estimation of Engine Intake Air Mass Flow using a generic Speed-Density method

open access: yesJournal of Middle European Construction and Design of Cars, 2014
Measurement of real driving emissions (RDE) from internal combustion engines under real-world operation using portable, onboard monitoring systems (PEMS) is becoming an increasingly important tool aiding the assessment of the effects of new fuels and ...
Vojtíšek Michal, Kotek Martin
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane   +10 more
wiley   +1 more source

A Simplified 4-DOF Dynamic Model of a Series-Parallel Hybrid Electric Vehicle

open access: yesWorld Electric Vehicle Journal
To research the dynamic response of a new type of dedicated transmission for a hybrid electric vehicle, a detailed dynamics model should be built. However, a model with too many degrees of freedom has a negative effect on controller design, which means ...
Lihong Dai   +4 more
doaj   +1 more source

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