Results 61 to 70 of about 481,400 (339)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

open access: yesFEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl   +13 more
wiley   +1 more source

The Diesel Fuel Post-Injection into Engine Cylinder as Method of Nox Reduction

open access: yesCommunications, 2003
The possibilities of limiting the emission of nitrogen oxides in the cylinder of the diesel engine by means of its design and operating parameters are limited. This is why studies of the effectiveness of various methods for NOx reduction in exhaust gases
Zygmunt Szlachta, Jerzy Cisek
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Acoustic Metamaterials: A Potential for Cabin Noise Control in Automobiles and Armored Vehicles

open access: yes, 2016
The aim of this paper is to provide an overview of the existing industrial practices used for cabin noise control in various industries such as automotive, marine, aerospace, and defense.
L. Ang, Y. Koh, H. Lee
semanticscholar   +1 more source

A survey study of steering wheel vibration and sound in automobiles at idle [PDF]

open access: yes, 2009
Copyright @ 2009 Engineering Integrity SocietyThis work is supported by Shell Global Solutions UK for their sponsorship of this research as part of the activities of the EFII3 ...
Ajovalasit, M, Giacomin, J
core  

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Automobile country of origin related associations in Lithuanian market [PDF]

open access: yesTransport, 2007
Automobile is a high-involvement product that typically requires significant buyer’s attention when purchased. It is typical that country of origin (COO) of a purchased car is considered among other product characteristics. hough COO concept is analysed
S. Urbonavičius, V. Dikčius, R. Časas
doaj  

Vehicle driver identification system based on biometric data

open access: yesИнтеллект. Инновации. Инвестиции, 2020
The article discusses the problems associated with monitoring the observance of work and rest regimes by taxi drivers, which, together with an increase in the number of taxi services, lead to an increase in the number of road traffic accidents.
E. S. Kozin, A. V. Bazanov
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

Putting the Car Before the Horse: The Diffusion of the Automobile and the Rise of Technocratic Primacy

open access: yesHistories
A key question in the literature of technology in society is the degree to which technology is a product of society and vice versa. A related question is how the differing cross-causal lines between the two change both technological and social forms ...
Cameron Elliott Gordon
doaj   +1 more source

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