Results 151 to 160 of about 724,055 (291)

Recurrent Hypothermia and Autonomic Dysfunction Secondary to Shapiro Syndrome. [PDF]

Ann Clin Transl Neurol
Kumar N, Johnson J, Watkins S, Mulroy E.
europepmc   +1 more source

Semantic Web Meets Autonomic Ubicomp

, 2004
The placement of autonomic systems’ management functionality into a ubiquitous computing environment is a difficult task due to the lack of systems’ resources and the need for ‘intelligence’ to ensure that the system is selfhealing/ organising or ...
McCann, J, Payne, T, Gawesh Jawaheer, Roxana Belecheanu, Terry Payne, Belecheanu, R A, Asher Hoskins, Hoskins, A, Jawaheer, G, Julie A. Mccann   +9 more
core  

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source

The relation between physical activity and cardiac autonomic dysfunction in patients with chronic obstructive pulmonary disease. [PDF]

PLoS One
Hermans F, Arents E, Blondeel A, Janssens W, Cardinaels N, Calders P, Troosters T, Derom E, Demeyer H.   +8 more
europepmc   +1 more source

D4F‐Functionalized Ceria Nanozyme‐CasRx Platform Suppresses STING and Reprograms the Renal Immune Niche in Acute Kidney Injury

Advanced Science, EarlyView.
D4F‐functionalized ceria nanozyme–CasRx nanoparticles preferentially target renal macrophages through SR‐B1‐mediated uptake in ischemia–reperfusion injury. Ceria scavenges excessive ROS, while CasRx silences STING signaling, shifting macrophages toward a less inflammatory, pro‐resolving state and increasing the proportion of regulatory T cells.
Weibo Chen, Ming Li, Xuesheng Wang, Jiajia Sun, Ziyuan Zhang, Yongfeng Gong, Benkang Shi, Nengwang Yu, Yunuo Mao, Shengtian Zhao, Xiulin Zhang, Liqiang Guo   +11 more
wiley   +1 more source

Gut Microbiota, Neuroinflammation, and Autonomic Dysfunction in Neurodegenerative Diseases: A Systematic Review of Mechanistic and Translational Evidence. [PDF]

Cureus
Alauddin W, Srivastava C, Goyal P, Shukla M, Garg DK, Prajesh BR, Singh S, Shaikh FI, Khairnar S.   +8 more
europepmc   +1 more source

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

Spinal cord involvement and cardiovascular autonomic dysfunction in Parkinson's disease. [PDF]

Sci Rep
Chougar L, Lejeune FX, Cohen-Adad J, Landelle C, Guay-Paquet M, Newton J, Valosek J, Biondetti E, Jovanovic C, Wennberg K, Dagher A, Doyon J, Pyatigorskaya N, Sambin S, Mangone G, Corvol JC, Arnulf I, Vidailhet M, Lehéricy S.   +18 more
europepmc   +1 more source

Antigen‐Detected NMR for Minimal Epitope Engineering and Structure‐Guided Selection of a NaV1.7‐Selective Nanobody

Advanced Science, EarlyView.
A minimal extracellular epitope from voltage‐gated sodium channel NaV1.7 was engineered into an isotope‐labelled antigen for antigen‐detected nuclear magnetic resonance (NMR). Together with AlphaFold2 (AF2), this enabled structure‐guided selection of R4C8, a human NaV1.7‐selective nanobody that labels fixed NaV1.7‐expressing cells and produces staining
Junyu Liu, Wanlin Chen, Ben Cristofori‐Armstrong, Theo Crawford, Kai‐En Chen, Peng Xie, Rainbow Wing Bo Chan, Yifei Zhu, Mimi Golder, Anneka Pereira Schmidt, Jennifer D. Naughton, Nicholas D. Condon, Åsa Andersson, Farhad Dehkhoda, Kirsten L. McMahon, Tabea Klasfauseweh, Ashvriya Thapa, Hue Tran, Poanna Tran, Sina Jami, Lotten Ragnarsson, Sebastian G. B. Furness, Jennifer R. Deuis, Brett M. Collins, Wai‐Hong Tham, Indira Prasadam, Irina Vetter, Mehdi Mobli   +27 more
wiley   +1 more source

Adult-Onset Alexander Disease Presenting as Atypical Parkinsonism and Autonomic Dysfunction: A Case Series. [PDF]

J Clin Med
Fang J, Wang Z, Feng T, Jiang Y.
europepmc   +1 more source