Results 221 to 230 of about 1,429,663 (251)

SCTR–Expressing Astrocyte–Serotonergic Neuron Signaling Drives Sexual Dimorphism in Depression Through KAT7/H4ac–Foxc2 Epigenetic Axis in an AMPK‐Dependent Manner

Advanced Science, EarlyView.
Astrocytic SCTR modulates depressive‐related phenotypes via AMPKα1, whereas lowered Mt1 blunts Megalin‐dependent AMPKα2 signaling in serotonergic neurons. Diminished AMPKα2 hinders KAT7 nuclear translocation, curtails KAT7 occupancy and H4K8ac at the Foxc2 promoter, and represses Foxc2 transcription, revealing cell‐type‐specific AMPK‐linked epigenetic ...
Fantao Meng, Jing Liu, Juanjuan Dai, Min Wu, Wentao Wang, Mengdi Zhang, Shujun Jiang, Yifan Cao, Lihong Xu, Lin Du, Dan Wang, Di Zhao, Gaofeng Qin, Dong Wang, Wei Li, Chen Li   +15 more
wiley   +1 more source

REenergizeME: intermittent hypoxia-hyperoxia treatment for myalgic encephalomyelitis/chronic fatigue syndrome-protocol for a randomised, placebo-controlled trial. [PDF]

BMJ Open
Nochi M, Kristensen SK, Mehrani N, Guerreiro I, Nørholm IMD, Chandra S, Olufsen M, Gudbergsen LR, Brinth LS, Stokholm R, Karlsson P, Tankisi H, Mehlsen J, Foldager CB, Olsen RKJ.   +14 more
europepmc   +1 more source

Versatile Microgel Platform for Intervertebral Disc Degeneration Therapy: Targeting Pericyte‐Mediated Fibrosis and Protecting Nucleus Pulposus Cells

Advanced Science, EarlyView.
The engineered MMS@TRP microgel enables targeted, acid‐responsive delivery of a miR‐21 inhibitor to pericytes. It effectively suppresses disc fibrosis by inhibiting TGF‐β signaling while protecting nucleus pulposus cells via sustained, antioxidant tannic acid release.
Fei Ma, Zhen Zhao, Chuan Guo, Yuheng Liu, Yu Wang, Dengbo Yao, Weiqiang Lan, Dejun Zhong, Chen Fan, Yao He, Mei Zhang, Qingquan Kong, Yunfeng Lin   +12 more
wiley   +1 more source

Acute Cauda Equina Syndrome With Clinicoradiological Discordance Treated via Unilateral Biportal Endoscopy: A Case Report. [PDF]

Case Rep Neurol Med
Wu Q, Zhang Y, Han J, Guo W, Liao B.
europepmc   +1 more source

MN•CS•IO System: Cross‐Species Study for HBB Function in High‐Altitude Hypoxia Adaptation

Advanced Science, EarlyView.
We developed an integrative mesh‐nanorod sorting, chitosan nanoparticle delivery, and intraosseous injection (MN•CS•IO) system to investigate HBB in high‐altitude hypoxia adaptation. Transplanting Tibetan animals' HBB‐modified Lin‐ cells into mice achieved 95.59% transfection efficiency and 8.15% HBB expression. High‐altitude HBB recipients upregulated
Wenqiao Hui, Lin Mao, Binggang Li, Hanyue Kang, Zhengquan Tang, Sheng Chen, Hui Yang, Yu Qiao, Huiqian Ding, Yuhuan Wang, Min Li, Junjie Hu, Shoudong Ye, Xin Wang, Xiaobin Xu, Yupeng Wang, Tana Wuren, Qian Ban, Baowei Zhang   +18 more
wiley   +1 more source

Clinical features and pathogenesis of Sjogrens disease related peripheral neuropathy and their relevance to clinical trials. [PDF]

Commun Med (Lond)
Pucino V, Nayar S, Fehmi J, Baldini C, Bowman SJ, Fisher BA.   +5 more
europepmc   +1 more source

Cardioneuroablation Restoring Atrioventricular Conduction in Brugada Syndrome: A Device-Free Approach. [PDF]

JACC Case Rep
Chipa-Ccasani F, Brugada J, Luján AL, Martínez-Barrios E, Díez-Escuté N, Merchan Pinto EF, Campuzano O, Cruzalegui J, Greco A, Sarquella-Brugada G.   +9 more
europepmc   +1 more source

Stellate ganglion block achieves remission of recurrent head-and-neck plaque psoriasis: A case report. [PDF]

J Int Med Res
Liu J, Zhang Z, Liu T.
europepmc   +1 more source

Diagnosis and treatment of abdominal pain of spinal origin: a case report. [PDF]

J Med Case Rep
He C, Liu Y, Bao R, Zhang H, Chen H.
europepmc   +1 more source

Chronic Inflammatory Demyelinating Polyneuropathy in a Patient With Autoimmune Autonomic Ganglionopathy: A Case Report. [PDF]

Cureus
Taylor EN, Hansen JE, White J.
europepmc   +1 more source