Results 31 to 40 of about 1,429,663 (251)

Early diagnosis of neuropathy in leprosy: comparing diagnostic tests in a large prospective study (the INFIR Cohort Study) [PDF]

, 2008
BackgroundLeprosy is the most frequent treatable neuromuscular disease. Yet, every year, thousands of patients develop permanent peripheral nerve damage as a result of leprosy.
Wilder-Smith, Einar P, Pramila Barkataki, van Brakel, Wim H, van Brakel Wim H., Wim H van Brakel, Diana N J Lockwood, Einar P Wilder-Smith, Nicholls Peter G., Peter G Nicholls, Wilder-Smith Einar P., Nicholls, Peter G, Lockwood Diana N. J., Das Loretta, INFIR Study Group, Nicholls, Peter G., Lockwood, Diana N.J, Das, Loretta, Barkataki, Pramila, Barkataki Pramila, van Brakel, W.H., Loretta Das, Wilder-Smith, Einar P., Lockwood, Diana NJ   +22 more
core   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autonomic diagnosis of anomalous network traffic. [PDF]

, 2010
Network traffic abnormalities pose one of the greatest threats for networked environments. Autonomic communications offer a solution: it should be possible to design network mechanisms that behave adaptively and respond to any anomalous phenomenon that ...
Pezaros, Dimitrios P., Marnerides, Angelos, Hutchison, David   +2 more
core   +5 more sources

Single-Electrode, Bidirectional Control of Heart Rate via Vagus Nerve Modulation in Rat Model

IEEE Transactions on Neural Systems and Rehabilitation Engineering
Electrical stimulation of somatic nerves has long been used as a treatment method for a wide range of diseases by increasing activity on a target nerve.
Shane A. Bender, David B. Green, Varun S. Thakkar, Hope L. Zimmerman, Mohamed Elazab, Kevin L. Kilgore, Tina L. Vrabec   +6 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Noninvasive ¹³C-octanoic acid breath test shows delayed gastric emptying in patients with amyotrophic lateral sclerosis [PDF]

, 1999
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive loss of motor neurons. However, ALS has been recognized to also involve non-motor systems.
Folwaczny, Christian, Lochmüller, H., Müller-Felber, W., Schroeder, M., Riepl, R. L., Toepfer, Marcel, Pongratz, D.   +6 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Blockade of the Proximal Pancreatic C Fiber Enhances Insulin Sensitivity in Rats

Obesities
Numerous reports have been published on the putative mechanisms of development of insulin resistance in diabetes mellitus. However, no unified view has been established yet, especially in regard to involvement of the nervous system in the regulation of ...
Masataka Kusunoki, Daisuke Sato, Fumiya Hisano, Kazuhiko Tsutsumi, Tetsuro Miyata   +4 more
doaj   +1 more source

Morphological reasoning of paraaortal surgical access for an abdominal aortic neural plexus in pet dogs

BIO Web of Conferences, 2020
Despite a great number of studied and development of new treatment of various diseases, there is a lack of effective surgical access pathways to an abdominal autonomic nerve in small predatory animals.
Skubko Oleg Romanovich, Shushakova Olga Nikolaevna   +1 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source