Results 141 to 150 of about 146,347 (350)

Bilirubin as a Modulator of WNK1 Protein Signaling: Implications for Neuroinflammatory Diseases

Advanced Science, EarlyView.
ABSTRACT Previously regarded merely as a potentially harmful waste product of heme catabolism, bilirubin has now emerged as a pleiotropic molecule with potent antioxidant, anti‐inflammatory, and hormone‐like properties. Recent findings have revealed protective effects against cardiovascular, metabolic, autoimmune, and neoplastic diseases, as well as ...
Sri Jayanti, Libor Vítek, Silvia Gazzin, Claudio Tiribelli   +3 more
wiley   +1 more source

Analysis of the Adrenal Gland Is Useful for Evaluating Pathology of the Peripheral Autonomic Nervous System in Lewy Body Disease [PDF]

, 2007
Yuichi Fumimura, Masako Ikemura, Yuko Saito, Renpei Sengoku, Kazutomi Kanemaru, Motoji Sawabe, Tomio Arai, Genta Ito, Takeshi Iwatsubo, Masashi Fukayama, Hidehiro Mizusawa, Shigeo Murayama   +11 more
openalex   +1 more source

Regulated peristalsis into the acidic region of the _Drosophila_ larval midgut is controlled by a novel component of the Autonomic Nervous System [PDF]

, 2009
The underlying cellular and molecular mechanisms that regulate and coordinate critical physiological processes such as peristalsis are complex, often cryptic, and involve the integration of multiple tissues and organ systems within the organism.
Brooke Ann Johnson, Dennis Richard LaJeunesse, Grzegorz Zapotoczny, Jason Presnell, Kathleen K. Catignas   +4 more
core   +1 more source

First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria

Advanced Science, EarlyView.
We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena, Marcelino Telechea, Daniel Fernández, Alba García‐Martín, Ángeles Canales, Silvia Ortega‐Gutiérrez   +5 more
wiley   +1 more source

Editorial: Autonomic Nervous System and Cardiovascular Diseases: From Brain to Heart

Frontiers in Physiology, 2022
Yueyi Wang, Yueyi Wang, Yueyi Wang, Yueyi Wang, Liping Zhou, Liping Zhou, Liping Zhou, Liping Zhou, Hong Jiang, Hong Jiang, Hong Jiang, Hong Jiang, Lilei Yu, Lilei Yu, Lilei Yu, Lilei Yu   +15 more
doaj   +1 more source

Nanoparticle‐Mediated Immunometabolic‐Epigenetic Remodeling Enhances Schwann Cell‐Macrophage Interaction for Sciatic Nerve Regeneration

Advanced Science, EarlyView.
A biomimetic Prussian White nanoparticle (PW) is engineered to achieve long‐term local retention and orchestrate immunometabolic‐epigenetic remodeling for sciatic nerve regeneration. PW directly targets hexokinase 2 to suppress glycolysis, thereby elevating α‐ketoglutarate and driving Kdm4a/b‐mediated demethylation of H3K9me3.
Wenying Xu, Rongrong Wu, Zhicheng Liu, Hongyu Yan, Huan Zhang, Yuanyi Zheng, Xiaojun Cai   +6 more
wiley   +1 more source

Reliability of short-term measurement of heart rate variability on rest in individuals with temporomandibular disorder

Scientific Reports
Individuals with temporomandibular disorder (TMD) experience autonomic dysfunction, which disrupts the balance between the sympathetic and parasympathetic nervous systems.
Rodrigo Costa Cutrim, Aldair Darlan Santos-de-Araújo, Cassius Iury Anselmo-e-Silva, Janaina de Oliveira Brito Monzani, Rudys Rodolfo de Jesus Tavarez, Maria Cláudia Gonçalves, Etevaldo Matos Maia-Filho, Audrey Borghi-Silva, Almir Vieira Dibai-Filho, Daniela Bassi-Dibai   +9 more
doaj   +1 more source

Cars2‐Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2

Advanced Science, EarlyView.
We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng, Hongyong Song, Yin Long, Kaimin Wu, Yinkun Fu, Wenkai Zhou, Wenyan Li, Zhe Shi, Xu‐Yun Zhao   +8 more
wiley   +1 more source

Long-range dependencies in heart rate signals- revisited

, 2005
The RR series extracted from human electrocardiogram signal (ECG) is considered as a fractal stochastic process. The manifestation of long-range dependencies is the presence of power laws in scale dependent process characteristics.
Aleksandra Dudkowska, Amaral, Andrzej Rynkiewicz, Ashkenazy, Bacry, Bacry, Bak, Barral, Bassingthwaighte, Benzi, Berg, Costa, Costa, Danuta Makowiec, Falconer, Fauchier, Glass, Glass, Goldberger, Gregory, Havlin, Ivanov, Ivanov, Ivanov, Ivanov, Kantelhardt, Kiyono, Kotani, Lashermes, Lin, Mandelbrot, Mandelbrot, Mandelbrot, Marcin Zwierz, Meyer, Muzy, Muzy, Peng, Peng, Rafał Gała¸ska, Riedi, Schertzer, Stanley, Struzik, Teich, Yamamoto, Yang   +46 more
core   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source