Results 41 to 50 of about 38,384 (267)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Revista Vasca de Administración Pública, 2017 Intergovernmental relations in Spain have been characterized by mistrust and a lack of collaboration among political actors. In this context of intergovernmental controversy, this article presents a case of success related to several good practices ...
María Ángeles Abellán López +1 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
El voto preferencial en las Comunidades Autónomas: propuestas y condicionantes jurídicos [PDF]
Revista d'Estudis Autonòmics i Federals, 2019 In recent years, mechanisms have been activated in order to carry out political reforms in the Autonomous Communities, due to the greater fragmentation that exists in regional parliaments and the presence of political parties that support institutional ...
Carlos Fernández-Esquer +1 more
doaj
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Oñati Socio-Legal Series, 2016 Estamos asistiendo a un intenso debate en torno a la necesidad de generar un proceso regeneración democrática en el contexto actual de la crisis institucional y desafección política.
Reyes Pérez Alberdi
doaj
Urban ScienceData is the starting point for generating information and knowledge in the decision-making process. Open data, which is information disclosed free of charge through open licenses and reusable formats, has great potential for value creation.
Ricardo Curto-Rodríguez +3 more
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Derechos y libertades y Estado de las Autonomías
Revista Vasca de Administración Pública, 2010 The descentralization of Spain which began in the constituant process meant a new territorial model of State, in-between a federal State and a centralized one.
M.ª Isabel Álvarez Vélez +2 more
doaj +1 more source
« Etat composé » ou décomposé ?
L'Espace Politique, 2010 The Spanish Constitution of 1978 shares the power between the State and the Autonomous Communities. Over the past three decades, the principle of this "compound state" has become reality.
Nacima Baron
doaj +1 more source