Results 131 to 140 of about 1,101,470 (312)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Autonomous Driving in Roundabout Maneuvers Using Reinforcement Learning with Q-Learning

, 2019
Navigating roundabouts is a complex driving scenario for both manual and autonomous vehicles. This paper proposes an approach based on the use of the Q-learning algorithm to train an autonomous vehicle agent to learn how to appropriately navigate ...
Laura García Cuenca, García Cuenca, Laura, Fernández Andrés, Javier, Aliane, Nourdine, Enrique Puertas, Puertas Sanz, Enrique, Javier Fernandez Andrés, Nourdine Aliane   +7 more
core   +1 more source

Ethical Considerations of the Trolley Problem in Autonomous Driving: A Philosophical and Technological Analysis

World Electric Vehicle Journal
The trolley problem has long posed a complex ethical challenge in the field of autonomous driving technology. By constructing a general trolley problem model, this paper demonstrates that the default loss assumption is a necessary condition for the ...
Hao Zhan, Dan Wan
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

DriverGym: Democratising Reinforcement Learning for Autonomous Driving

Despite promising progress in reinforcement learning (RL), developing algorithms for autonomous driving (AD) remains challenging: one of the critical issues being the absence of an open-source platform capable of training and effectively validating the ...
Bergamini, Luca, Ondruska, Peter, Kothari, Parth, Alahi, Alexandre, Perone, Christian   +4 more
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ventilation control of road tunnels towards disturbance suppression

Scientific Reports
In recent years, research on ventilating tunnels has become increasingly important. However, the impact of external disturbances on ventilating systems has been largely ignored.
Yimeng Wang, Changxuan Zhou, Qitao Zhao, Ruihan Jia, Wei Wu   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Lightweight Machine Learning-Based QoS Optimization for Multi-UAV Emergency Communications in FANETs

Drones
Flying Ad Hoc Networks (FANETs) composed of multiple unmanned aerial vehicles (UAVs) are a promising solution for emergency wireless communications when terrestrial infrastructure is unavailable.
Jonathan Javier Loor-Duque, Santiago Castro-Arias, Juan Pablo Astudillo León, Clayanela J. Zambrano-Caicedo, Iván Galo Reyes-Chacón, Paulina Vizcaíno, Leticia Lemus Cárdenas, Manuel Eugenio Morocho-Cayamcela   +7 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source