Results 121 to 130 of about 1,377,038 (265)

Ethical Considerations of the Trolley Problem in Autonomous Driving: A Philosophical and Technological Analysis

World Electric Vehicle Journal
The trolley problem has long posed a complex ethical challenge in the field of autonomous driving technology. By constructing a general trolley problem model, this paper demonstrates that the default loss assumption is a necessary condition for the ...
Hao Zhan, Dan Wan
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Ventilation control of road tunnels towards disturbance suppression

Scientific Reports
In recent years, research on ventilating tunnels has become increasingly important. However, the impact of external disturbances on ventilating systems has been largely ignored.
Yimeng Wang, Changxuan Zhou, Qitao Zhao, Ruihan Jia, Wei Wu   +4 more
doaj   +1 more source

Autonomous Driving in Roundabout Maneuvers Using Reinforcement Learning with Q-Learning

, 2019
Navigating roundabouts is a complex driving scenario for both manual and autonomous vehicles. This paper proposes an approach based on the use of the Q-learning algorithm to train an autonomous vehicle agent to learn how to appropriately navigate ...
Laura García Cuenca, García Cuenca, Laura, Fernández Andrés, Javier, Aliane, Nourdine, Enrique Puertas, Puertas Sanz, Enrique, Javier Fernandez Andrés, Nourdine Aliane   +7 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Transition from machine intelligence to knowledge intelligence: A multi-agent simulation approach to technology transfer

Journal of Intelligent Systems
The traditional machine intelligence system lacks deep understanding and reasoning ability. This study took the automatic driving system in multi-agent as an example to bring higher-level intelligence and decision-making ability to automatic driving ...
Gong Shuanglei
doaj   +1 more source

Lightweight Machine Learning-Based QoS Optimization for Multi-UAV Emergency Communications in FANETs

Drones
Flying Ad Hoc Networks (FANETs) composed of multiple unmanned aerial vehicles (UAVs) are a promising solution for emergency wireless communications when terrestrial infrastructure is unavailable.
Jonathan Javier Loor-Duque, Santiago Castro-Arias, Juan Pablo Astudillo León, Clayanela J. Zambrano-Caicedo, Iván Galo Reyes-Chacón, Paulina Vizcaíno, Leticia Lemus Cárdenas, Manuel Eugenio Morocho-Cayamcela   +7 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source