Results 111 to 120 of about 1,377,038 (265)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
, 2021 Wheeled mobile driving simulators (WMDS) intend to cue the motion of road vehicles by moving a tire-bound, electrically driven, omnidirectional platform.
Albrecht, Torben +9 more
core
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Radar Perception of Multi-Object Collision Risk Neural Domains during Autonomous Driving
The analysis of the state of the literature in the field of methods of perception and control of the movement of autonomous vehicles shows the possibilities of improving them by using an artificial neural network to generate domains of prohibited ...
Józef Lisowski
core +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
DriverGym: Democratising Reinforcement Learning for Autonomous Driving
Despite promising progress in reinforcement learning (RL), developing algorithms for autonomous driving (AD) remains challenging: one of the critical issues being the absence of an open-source platform capable of training and effectively validating the ...
Bergamini, Luca +4 more
core
, 2022 Το θέμα το οποίο αναλύεται στην εργασία αυτή είναι η αυτόνομη οδήγηση και τα αυτό-οδηγούμενα οχήματα. Η ραγδαία εξέλιξη της τεχνολογίας τα τελευταία έτη έχει επηρεάσει στον μέγιστο βαθμό την καθη- μερινότητα του ανθρώπου.
Αρβανίτης, Σάββας +2 more
core
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Validating on-the-limit properties of a driving simulator
, 2014 The paper describes a validation model for both subjective and objective comparison of on-the-limit properties of a driving simulator. VTI moving base driving simulator, SIM III, has been used with three different versions of VTI’s vehicle model, for ...
Kharrazi, Sogol +4 more
core +1 more source