Results 111 to 120 of about 1,101,470 (312)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
, 2021 Wheeled mobile driving simulators (WMDS) intend to cue the motion of road vehicles by moving a tire-bound, electrically driven, omnidirectional platform.
Albrecht, Torben +9 more
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Developing a Risk Recognition System Based on a Large Language Model for Autonomous Driving
Engineering ProceedingsAutonomous driving systems have the potential to reduce traffic accidents dramatically; however, conventional modules often struggle to accurately detect risks in complex environments.
Donggyu Min, Dong-Kyu Kim
doaj +1 more source
Study on Following Car Model with Different Driving Styles Based on Proximal PolicyOptimization Algorithm [PDF]
Jisuanji kexueAutonomous driving plays a crucial role in reducing traffic congestion and improving driving comfort.It remains of significant research importance to enhance public acceptance of autonomous driving technology.Customizing different driving styles for ...
YAN Xin, HUANG Zhiqiu, SHI Fan, XU Heng
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Nihon Kikai Gakkai ronbunshuThis paper aims to clarify the behavior and damage conditions of batteries when multi-rotor unmanned aerial vehicles (drones) in horizontal flight collide with a structure to obtain the engineering knowledge that serves to consider the method of the ...
Kengo TAKAHASHI +3 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Other title: Teen safe driving in Connecticut
, 2015 Annual; "Annual Report on Effectiveness of Connecticut's Teen Driving Laws.
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A Systemic Approach Integrating Driving Cycles for the Design of Hybrid Locomotives [PDF]
, 2013 Driving cycles are essential in hybrid locomotive design by conditioning their size and performance. This paper introduces a new systemic approach to hybrid locomotive design, taking real-world driving cycles into account.
Jaafar, Amine +2 more
core +1 more source