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Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source
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Autonomous driving

Proceedings of the 7th International Conference on Automotive User Interfaces and Interactive Vehicular Applications, 2015
Self-driving vehicles are able to drive on their own as long as the requirements of their autonomous systems are met. If the system reaches the boundary of its capabilities, the system has to de-escalate (e.g. emergency braking) or hand over control to the human driver.
Marcel Walch   +3 more
  +4 more sources

Autonomous Driving

International Journal of Mobile Human Computer Interaction, 2017
Autonomous vehicles will need de-escalation strategies to compensate when reaching system limitations. Car-driver handovers can be considered one possible method to deal with system boundaries. The authors suggest a bimodal (auditory and visual) handover assistant based on user preferences and design principles for automated systems.
Marcel Walch   +3 more
openaire   +1 more source

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