Results 61 to 70 of about 1,683,698 (298)

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

The Relationship Between Autonomous Motivation for Exercise, Self-Compassion and Physical Activity [PDF]

, 2022
This series of studies investigated the relationships between self-compassion, physical activity, and autonomous motivation for exercise. The purpose of Study 1 was to examine if autonomous motivation for exercise moderates the association between self ...
Johnston, Mackenzie Breanna
core   +1 more source

Why Do You Work as a Teacher? Associations Between Teachers’ Work Motivation, Teaching Quality, and Well-being

Psichologija
This cross-sectional study investigated correlations between six types of work motivation (intrinsic motivation; integrated, identified, introjected, and external regulation; and amotivation), teaching quality, and well-being among primary school ...
Gintautas Šilinskas, Saulė Raižienė
doaj   +3 more sources

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Motivation Dynamics for Autonomous Composition of Navigation tasks

IEEE Transactions on Robotics, 2021
In this article, we physically demonstrate a reactive sensorimotor architecture for mobile robots whose behaviors are generated by motivation dynamics. Motivation dynamics uses a continuous dynamical system to reactively compose low-level control vector fields using valuation functions that capture the potentially competing influences of external ...
Paul B. Reverdy, Vasileios Vasilopoulos, Daniel E. Koditschek   +2 more
openaire   +4 more sources

Associations between autonomous functioning, motivation, civic engagement, and voting

, 2020
Is autonomous motivation for voting and/or individual differences in autonomous functioning positively associated with voting-related intentions, attitudes, and behaviors and/or actual voting ...
Alex Fine, Bradley D. Mattan, Christin Scholz, Emily Falk, Hang-Yee Chan, Michael X Delli Carpini, chris callison-burch, Nicole Cooper, Danielle Cosme, Glen Coppersmith, Aditya Kashyap, Jose Carreras Tartak, Alexandra (Ally) M. Paul   +12 more
core   +1 more source

Students’ Motivation for Honors Programs in the Netherlands

SAGE Open
This study aimed to examine student motivation for honors programs using two types of motivation (autonomous and controlled) of Dutch traditional students, Dutch non-traditional students, and international students.
Neha Basnet, Anouk Wouters, Rashmi A. Kusurkar   +2 more
doaj   +1 more source

Intrinsic Motivation Systems for Autonomous Mental Development [PDF]

IEEE Transactions on Evolutionary Computation, 2007
Exploratory activities seem to be intrinsically rewarding for children and crucial for their cognitive development. Can a machine be endowed with such an intrinsic motivation system? This is the question we study in this paper, presenting a number of computational systems that try to capture this drive towards novel or curious situations.
Pierre-Yves Oudeyer, Frédéric Kaplan, Verena Vanessa Hafner   +2 more
openaire   +2 more sources

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Motivations, work-family enrichment and job satisfaction: An indirect effects model [PDF]

, 2011
Self Determination Theory (SDT) recognises that people may experience their motivations as either coming from within themselves (autonomous) or from outside of themselves (controlled).
Haar, Jarrod, Roche, Maree
core   +1 more source