Results 91 to 100 of about 181,638 (266)

The microbiome in human skin aging

open access: yesFEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Distributed strategies for pursuit-evasion of high-order integrators

open access: yesAutonomous Intelligent Systems
This paper presents decentralized solutions for pursuit-evasion problems involving high-order integrators with intracoalition cooperation and intercoalition confrontation.
Panpan Zhou   +3 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Distributed gradient-free and projection-free algorithm for stochastic constrained optimization

open access: yesAutonomous Intelligent Systems
Distributed stochastic zeroth-order optimization (DSZO), in which the objective function is allocated over multiple agents and the derivative of cost functions is unavailable, arises frequently in large-scale machine learning and reinforcement learning ...
Jie Hou, Xianlin Zeng, Chen Chen
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Human feedback enhanced autonomous intelligent systems: a perspective from intelligent driving

open access: yesAutonomous Intelligent Systems
Artificial intelligence empowers the rapid development of autonomous intelligent systems (AISs), but it still struggles to cope with open, complex, dynamic, and uncertain environments, limiting its large-scale industrial application.
Kang Yuan   +4 more
doaj   +1 more source

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