Results 71 to 80 of about 1,163,450 (291)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Autonomous Intelligent SystemsAutonomous driving systems (ADS) are at the forefront of technological innovation, promising enhanced safety, efficiency, and convenience in transportation. This study investigates the potential of end-to-end reinforcement learning (RL) architectures for
Ângelo Morgado +3 more
doaj +1 more source
Devaney chaos in non-autonomous discrete systems
, 2016 This paper is concerned with Devaney chaos in non-autonomous discrete systems. It is shown that in its definition, the two former conditions, i.e., transitivity and density of periodic points, in a set imply the last one, i.e., sensitivity, in the case ...
Shao, Hua, Shi, Yuming, Zhu, Hao
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Shapley value: from cooperative game to explainable artificial intelligence
Autonomous Intelligent SystemsWith the tremendous success of machine learning (ML), concerns about their black-box nature have grown. The issue of interpretability affects trust in ML systems and raises ethical concerns such as algorithmic bias.
Meng Li +3 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
A nonlinear optimal control approach for 3-DOF four-cable driven parallel robots
Autonomous Intelligent SystemsIn this article, a nonlinear optimal control approach is proposed for the dynamic model of 3-DOF four-cable driven parallel robots (CDPR). To solve the associated nonlinear optimal control problem, the dynamic model of the 3-DOF cable-driven parallel ...
G. Rigatos, M. Abbaszadeh, J. Pomares
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source