Results 61 to 70 of about 1,163,450 (291)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Enhanced bearing RUL prediction based on dynamic temporal attention and mixed MLP

Autonomous Intelligent Systems
Bearings are critical components in machinery, and accurately predicting their remaining useful life (RUL) is essential for effective predictive maintenance. Traditional RUL prediction methods often rely on manual feature extraction and expert knowledge,
Zhongtian Jin, Chong Chen, Aris Syntetos, Ying Liu   +3 more
doaj   +1 more source

Compositional Verification for Autonomous Systems with Deep Learning Components

, 2018
As autonomy becomes prevalent in many applications, ranging from recommendation systems to fully autonomous vehicles, there is an increased need to provide safety guarantees for such systems.
A Komuravelli, C Chilton, C Chilton, CS Pasareanu, S Bogomolov, T Dreossi, T Kanungo   +6 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Safe motion planning and formation control of quadruped robots

Autonomous Intelligent Systems
This paper introduces a motion planning and cooperative formation control approach for quadruped robots and multi-agent systems. First, in order to improve the efficiency and safety of quadruped robots navigating in complex environments, this paper ...
Zongrui Ji, Yi Dong
doaj   +1 more source

Efficiently Combining Human Demonstrations and Interventions for Safe Training of Autonomous Systems in Real-Time

, 2018
This paper investigates how to utilize different forms of human interaction to safely train autonomous systems in real-time by learning from both human demonstrations and interventions.
Goecks, Vinicius G., Gremillion, Gregory M., Lawhern, Vernon J., Valasek, John, Waytowich, Nicholas R.   +4 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Nonlinear optimal control for the five-axle and three-steering coupled-vehicle system

Autonomous Intelligent Systems
Transportation of heavy loads is often performed by multi-axle multi-steered heavy duty vehicles In this article a novel nonlinear optimal control method is applied to the kinematic model of the five-axle and three-steering coupled vehicle system. First,
G. Rigatos, M. Abbaszadeh, K. Busawon, P. Siano, M. Al Numay, G. Cuccurullo, F. Zouari   +6 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source