Results 121 to 130 of about 1,163,450 (291)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Point clouds to as-built two-node wireframe digital twin: a novel method to support autonomous robotic inspection

open access: yesAutonomous Intelligent Systems
Previous studies have primarily focused on converting point clouds (PC) into a dense mech of 3D finite element models, neglecting the conversion of PCs into as-built wireframe models with two-node elements for line elements such as beams and columns ...
Farzad Azizi Zade, Arvin Ebrahimkhanlou
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Autonome Systeme [PDF]

open access: yesInformatik-Spektrum, 2017
Werner Damm, Ralf Kalmar
openaire   +2 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Autonomic nervous system

open access: yesScholarpedia, 2008
Bill Blessing, Ian Gibbins
openaire   +1 more source

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