Results 131 to 140 of about 1,163,450 (291)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Multiple unmanned ship coverage and exploration in complex sea areas

Autonomous Intelligent Systems
This study addresses the complexities of maritime area information collection, particularly in challenging sea environments, by introducing a multi-agent control model for regional information gathering.
Feifei Chen, Qingyun Yu
doaj   +1 more source

Editorial: Robotics, Autonomous Systems and AI for Nonurgent/Nonemergent Healthcare Delivery During and After the COVID-19 Pandemic. [PDF]

Front Robot AI, 2022
Trejos AL, Atashzar SF, DiMaio SP, Pilarski PM, Tavakoli M.   +4 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

An uncertainty-aware domain adaptive semantic segmentation framework

Autonomous Intelligent Systems
Semantic segmentation is significant to realize the scene understanding of autonomous driving. Due to the lack of annotated real-world data, the technology of domain adaptation is applied so that the model is trained on the synthetic data and inferred on
Huilin Yin, Pengyu Wang, Boyu Liu, Jun Yan   +3 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

H-ViT: hardware-friendly post-training quantization for efficient vision transformer inference

Autonomous Intelligent Systems
Vision Transformers (ViTs) have achieved state-of-the-art performance on various computer vision tasks. However these models are memory-consuming and computation-intensive, making their deployment and efficient inference on edge devices challenging ...
Jing Liu, Jiaqi Lai, Xiaodong Deng, Caigui Jiang, Nanning Zheng   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Association rule mining for aircraft assembly process information based on fine-tuned LLM

Autonomous Intelligent Systems
The aircraft final assembly is a complex system, encompassing various aspects and multidimensional production factors. These numerous factors are interconnected, significantly impacting the efficiency of the final assembly process.
Jiaji Shen, Weidong Zhao, Xianhui Liu, Ning Jia, Yingyao Zhang   +4 more
doaj   +1 more source