Results 71 to 80 of about 391,832 (272)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Research on Game Confrontation of Unmanned Surface Vehicles Swarm Based on Multi-Agent Deep Reinforcement Learning

水下无人系统学报
Based on the background of future modern maritime combats, a multi-agent deep reinforcement learning scheme was proposed to complete the cooperative round-up task in the swarm game confrontation of unmanned surface vehicles (USVs).
Changdong YU, Xinyang LIU, Cong CHEN, Dianyong LIU, Xiao LIANG   +4 more
doaj   +1 more source

Beliefs and expectations of driving learners about autonomous driving

Transactions on Transport Sciences, 2020
Autonomous driving is a topic that generates great interest and social debate in the field of transport and road safety. Professionals working on vehicle technologies, telecommunications engineers, and vehicle manufacturers say it is an imminent reality ...
Ana Martí-Belda, Patricia Bosó, Ignacio Lijarcio   +2 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Evaluation of estimation approaches on the quality and robustness of collision warning system

, 2018
Vehicle safety is one of the most challenging aspect of future-generation autonomous and semi-autonomous vehicles. Collision warning systems (CCWs), as a proposed solution framework, can be relied as the main structure to address the issues in this area.
Baghbahari, Masoud, Hajiakhoond, Neda
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

PriorFusion: Unified integration of priors for robust road perception in autonomous driving

Communications in Transportation Research
With the growing interest in autonomous driving, there is an increasing demand for accurate and reliable road perception technologies. In complex environments without high-definition map support, autonomous vehicles must independently interpret their ...
Xuewei Tang, Mengmeng Yang, Tuopu Wen, Peijin Jia, Le Cui, Mingshan Luo, Kehua Sheng, Bo Zhang, Kun Jiang, Diange Yang   +9 more
doaj   +1 more source

CFD prediction of submarine motion during emergency surfacing

Zhongguo Jianchuan Yanjiu, 2019
[Objectives] Emergency surfacing is an important aspect of submarine vitality which is closely related to submarine safety. In order to master the motion laws of submarine during emergency surfacing performance,[Methods] this paper establishes a ...
LI Rijie, CHEN Qinglong, CHANG Wentian
doaj   +1 more source

System, Design and Experimental Validation of Autonomous Vehicle in an Unconstrained Environment

Sensors, 2020
In recent years, technological advancements have made a promising impact on the development of autonomous vehicles. The evolution of electric vehicles, development of state-of-the-art sensors, and advances in artificial intelligence have provided ...
Shoaib Azam, Farzeen Munir, Ahmad Muqeem Sheri, Joonmo Kim, Moongu Jeon   +4 more
doaj   +1 more source