Results 51 to 60 of about 39,993 (263)

Energy consequences of separating velocity planning and torque distribution in overactuated electric vehicles

Transportation Engineering
This paper investigates the energy consequences of determining the energy-optimal velocity profile and torque distribution sequentially versus jointly in a battery electric vehicle (BEV) with two electric motors, one per axle.
Juliette Torinsson, Mats Jonasson, Derong Yang, Bengt Jacobson, Toheed Ghandriz   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Effect of Waves on the Behavior of Emergent Buoyantly Rising Submarines Using CFD

Applied Sciences, 2020
Emergent buoyantly rising submarines encounter excess roll problems, partially owing to waves that significantly affect their behavior. This study predicts the behavior of a submarine, including when it rises in static water, beam sea, head wave ...
Qinglong Chen, Hongwei Li, Shudi Zhang, Jian Wang, Yongjie Pang, Qingyun Wang   +5 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Autonomous vehicles

Autonomous vehicle evangelists promise a bountiful ‘hands-free’ future. Relieved from steering, drivers can now do what they want: relax, watch TV, shop online, or chat to fellow passengers. Detractors see something different altogether: the voracious appetite of big tech, newly fetishized commodities, and the catastrophic environmental effects of ...
  +5 more sources

Stochastic Power Control Strategy for Hybrid Electric Propulsion Ships Using Markov Chain-Based Operational Data Augmentation

Journal of Marine Science and Engineering
Since power demand varies due to uncertain environmental conditions, a deterministic power control strategy for hybrid electric propulsion ships contains a limitation in securing robust performance.
Su Bin Choi, Soon Ho Hong, Sun Je Kim
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Fault Signal Emulation of Marine Turbo-Rotating Systems Based on Rotor-Gear Dynamic Interaction Modeling

Journal of Marine Science and Engineering
Rotating machinery is essential in various industrial fields, and growing demands for high performance under harsh operating conditions have heightened interest in fault diagnosis and prognostic technologies. However, a major challenge in fault diagnosis
Seong Hyeon Kim, Hyun Min Song, Se Hyeon Jeong, Won Joon Lee, Sun Je Kim   +4 more
doaj   +1 more source