Results 81 to 90 of about 391,832 (272)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Mass Platooning: Information Networking Structures for Long Platoons of Connected Vehicles

IEEE Open Journal of Intelligent Transportation Systems
Investigating Vehicle-to-everything (V2X) communication, we dive into the concept of vehicle platoons, a key innovation in transport systems, introducing a new era of cooperative driving.
Mahdi Razzaghpour, Babak Ebrahimi Soorchaei, Rodolfo Valiente, Yaser P. Fallah   +3 more
doaj   +1 more source

A single acoustic beacon-based positioning method for underwater mobile recovery of an AUV

International Journal of Advanced Robotic Systems, 2018
This article presents a navigation method for an autonomous underwater vehicle being recovered by a human-occupied vehicle. The autonomous underwater vehicle is considered to carry underwater navigation sensors such as ultra-short baseline, Doppler ...
Ziye Zhou, Yanqing Jiang, Ye Li, Cao Jian, Yeyi Sun   +4 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Numerical Analysis of Roll Hydrodynamic Coefficients of 2D Triangular Cylinder Using OpenFOAM

Journal of Marine Science and Engineering
Predicting the roll damping coefficient of a ship is a crucial factor in determining the dynamic stability of the vessel. However, a nonlinear analysis that considers the viscosity of the fluid is required to accurately estimate the roll damping ...
Eunchong Hwang, Kyung-Kyu Yang
doaj   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Multi-AUV Hunting Strategy Based on Regularized Competitor Model in Deep Reinforcement Learning

Journal of Marine Science and Engineering
Reinforcement learning has made significant progress in single-agent applications, but it still faces various challenges in multi-agent scenarios. This study investigates the application of reinforcement learning algorithms in a competitive game scenario
Yancheng Sui, Zhuo Wang, Guiqiang Bai, Hao Lu   +3 more
doaj   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Dynamic Mission Planning Framework for Collaborative Underwater Operations Using Behavior Trees

Journal of Marine Science and Engineering
This paper presents a behavior tree-based control architecture for end-to-end mission planning of an autonomous underwater vehicle (AUV) collaborating with a moving mothership in dynamic marine environments.
Seunghyuk Choi, Jongdae Jung
doaj   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source