Results 111 to 120 of about 2,414,319 (289)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Shared Autonomous Vehicles Effect on Vehicle-Km Traveled and Average Trip Duration

Journal of Advanced Transportation, 2018
Intermediate modes of transport, such as shared vehicles or ride sharing, are starting to increase their market share at the expense of traditional modes of car, public transport, and taxi.
Ana T. Moreno, Andrzej Michalski, Carlos Llorca, Rolf Moeckel   +3 more
doaj   +1 more source

Curse of rarity for autonomous vehicles. [PDF]

Nat Commun, 2022
The curse of rarity—the rarity of safety-critical events in high-dimensional variable spaces—presents significant challenges in ensuring the safety of autonomous vehicles using deep learning.
Liu HX, Feng S.
europepmc   +3 more sources

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Slim-neck by GSConv: A better design paradigm of detector architectures for autonomous vehicles

arXiv.org, 2022
Hulin Li, Jun Li, Hanbing Wei, Zheng Liu, Zhenfei Zhan, Qiliang Ren   +5 more
semanticscholar   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

A matched case-control analysis of autonomous vs human-driven vehicle accidents

Nature Communications
Despite the recent advancements that Autonomous Vehicles have shown in their potential to improve safety and operation, considering differences between Autonomous Vehicles and Human-Driven Vehicles in accidents remain unidentified due to the scarcity of ...
Mohamed Abdel-Aty, Shengxuan Ding
doaj   +1 more source

Effects of Anthropomorphic Driving Vehicles on Traffic Flow

Applied Sciences
Autonomous driving has many positive impacts, such as improving driver and passenger safety, comfort, and traffic efficiency, but all these advantages are based on people’s trust and acceptance of this mode of driving. Anthropomorphic driving can enhance
Xiaoyi Ma, Xiaowei Hu, Dieter Schramm, Shufen Wang   +3 more
doaj   +1 more source