Results 171 to 180 of about 137,500 (231)

Adipocyte‐Derived Exosomal miR‐5099 Mitigates M1 Macrophage Polarization and Adipose Inflammation via c‐Met/NF‐κB Axis to Improve Metabolic Health

Advanced Science, EarlyView.
Celastrol upregulates adipocyte‐derived exosomal miR‐5099, suppressing the macrophage c‐Met/NF‐κB axis to mitigate pro‐inflammatory M1 polarization and adipose inflammation. These miR‐5099‐enriched exosomes also act as endocrine signals targeting the liver, muscle, and adipocytes to significantly enhance systemic insulin sensitivity.
Ping Tang, Lixin Tai, Hongxia Xu, Dongliang Zhu, Jiajia Li, Hao Feng, Jinghui Cui, Shuhai Lin, Li‐jun Di, Li Wang   +9 more
wiley   +1 more source

The effect of grit on psychological well-being in collegiate athletes: the moderating role of social support. [PDF]

Front Sports Act Living
Lee KH, Oh KR.
europepmc   +1 more source

A Dual‐Responsive Versatile Nanohybrid Orchestrating Tumor Elimination and Tumor‐Associated Osteolysis Restoration via Sequential Release

Advanced Science, EarlyView.
The versatile CaO2@CuMOF@HAP nanohybrid demonstrates an outstanding MMP9/pH‐triggered release performance for sequential release of osteogenic growth peptide into deep‐seated tumor‐infiltrated bone destruction areas and dual ions into tumor cells, enabling efficient tumor‐associated osteolysis restoration and tumor elimination for more comprehensive ...
Lan Liu, Han‐Zhe Liu, Zhe‐Nan Liu, Tong Wang, Li‐Li Yu, Qiu‐Jing Li, Zi‐Yi Chen, Guo‐Feng Luo, Zheng‐Jun Shang   +8 more
wiley   +1 more source

Prevalence and associated factors for drug-related problems and polypharmacy identified by a pharmacist-led medication review in patients enrolled in a home healthcare program. [PDF]

BMC Geriatr
Salom-Garrigues C, Aragonès E, Giralt M, Campabadal Prats C, Bejarano-Romero F, Martín-Luján F, Romeu M, Canadell L.   +7 more
europepmc   +1 more source

Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis

Advanced Science, EarlyView.
Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Yuwei Zhang, Yuchen Wang, Binbin Li, Xin Li, Chenyu Liu, Yanhao Chen, Cheng Tian, Dongmei Wang, Xiaosong Gu, Chunping Jiang, Yuda Wei, Qiurong Ding   +11 more
wiley   +1 more source

The Arguments for Euthanasia and Physician-Assisted Suicide: Catholic Response [PDF]

, 2003
Rodriguez, Eduardo
core   +1 more source

Feline‐Inspired Robot Enabled by Combustion‐Driven Actuators for Agile Motion and High‐Payload Obstacle Traversal

Advanced Science, EarlyView.
Inspired by nature's competitive maneuvers, this study introduces a combustion‐driven soft actuator that powers a multi‐modal “Jump‐and‐Fly Catbot” (JFC). With millisecond response, high‐force output (over 70 times its weight) and precise control (error within 5%), the robot can jump, fly, hover, and escape from challenging environments, achieving ...
Hongkuan Ma, Yang Yang, Zhiguo He, Hongliang Ren, Pengcheng Jiao   +4 more
wiley   +1 more source

Development and validation of the AI dependence scale for Chinese undergraduates and a preliminary exploration. [PDF]

Front Psychol
Wu H, Ni H, Luo W, Wu T.
europepmc   +1 more source

Multi‐Organelle Stress‐Induced Paraptosis by a ROS‐Amplifying Nanocatalyst for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
The engineered TF‐Fe@LC nanoplatform programs paraptotic death via multipath ROS amplification that disrupts redox homeostasis, provoking mitochondrial dysfunction, autophagic blockade, and ER stress. This caspase‐independent process elicits robust immunogenic cell death, combining with αPD‐L1 to activate systemic CD8+ T‐cell immunity and suppress ...
Zhe Yu, Haozhe Ren, Hua Li, Jinghan Zhao, Miaomiao Cao, Tian Tang, Youbei Qiao, Liting Chen, Tiehong Yang, Hong Wu   +9 more
wiley   +1 more source