Results 131 to 140 of about 42,282 (208)

A <i>de novo VPS16</i> missense variant blocks autophagic flux and extends DYT-<i>VPS16</i> into infancy. [PDF]

Autophagy Rep
Gonzalez Saez-Diez E, Xue X, Ebrahimi-Fakhari D.   +2 more
europepmc   +1 more source

HMTA, a natural alkylphenol from <i>Ardisia virens</i> Kurz, obstructs autophagic flux to exert anti-pancreatic cancer activity. [PDF]

Am J Cancer Res
Chuang YF, Lee YR, Tsai WC.
europepmc   +1 more source

Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy

Angewandte Chemie International Edition, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source

Extracellular matrix sensing regulates intratumoral heterogeneity of autophagic flux. [PDF]

Cell
Assi M, Wang R, Kawaler EA, Sohn ASW, Zahidunnabi Dewan M, Kalfakakou D, Encarnacion-Rosado J, Kapner KS, Ganguly K, Paulo JA, Simeone DM, Aguirre AJ, Banh RS, Kimmelman AC.   +13 more
europepmc   +1 more source

Chemical and Molecular Strategies in Restoring Autophagic Flux in TDP-43 Proteinopathy. [PDF]

Molecules
Jamerlan A, Hulme J.
europepmc   +1 more source

RPS6KA3/RSK2-mediated phosphorylation of DRAM2 promotes lysosomal targeting and autophagic flux in melanoma. [PDF]

Autophagy
Lee GE, Nam SB, Moon E, Huh YH, Park HS, Na S, Kim JY, Han EH, Cho H, Choi JH, Cho YY, Bang G, Lee CJ.   +12 more
europepmc   +1 more source

CASTOR1 Regulates Humoral Immune Responses and Contributes to the Pathogenesis of Systemic Lupus Erythematosus

Arthritis &Rheumatology, EarlyView.
Objective CASTOR1 senses arginine and regulates mammalian target of rapamycin complex 1 (mTORC1), a central metabolic signaling molecule. This study aimed to elucidate the roles of CASTOR1 in humoral immune responses. Methods We analyzed human B cell transcriptomes from healthy controls and patients with systemic lupus erythematosus (SLE) via ...
Takeshi Kusuda, Toshihiko Komai, Takahiro Itamiya, Tatsuki Abe, Tomohisa Okamura, Keishi Fujio   +5 more
wiley   +1 more source

Beyond autophagic flux: selective autophagy adaptors and cargo prioritization in cardiac disease. [PDF]

Cardiol Plus
Espitia-Corredor JA, Olivares-Silva F, Alanis-Cubillos C, Deng Y, Wang ZV.   +4 more
europepmc   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

The Marine-Derived Cyclopentapeptide Turnagainolide B Suppresses Melanoma via Autophagic Flux Disruption and Inhibits Tumorigenesis In Vivo. [PDF]

Mar Drugs
Wan G, Zhao K, Wang M, Xu RH, Jin M, Liu L.   +5 more
europepmc   +1 more source