Results 91 to 100 of about 5,550,027 (295)
Autophagy: machinery and regulation
Microbial Cell, 2016 Macroautophagy/autophagy is an evolutionarily conserved cellular degradation process that targets cytoplasmic materials including cytosol, macromolecules and unwanted organelles.
Zhangyuan Yin +2 more
doaj +1 more source
Advanced Science, EarlyView.SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang +17 more
wiley +1 more source
Autophagosome Formation: Cutting the Gordian Knot at the ER [PDF]
Current Biology, 2018 Autophagosome biogenesis and the origins of its isolation membrane have been a long-standing unresolved question, with the endoplasmic reticulum and its membrane contact sites with other organelles remaining the prime suspect. This concept has now been reinforced by recent advances uncovering roles of several ER membrane proteins in autophagosome ...
Bhawana, Bissa, Vojo, Deretic
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Cell Death and Disease, 2019 Down syndrome (DS), a complex genetic disorder caused by chromosome 21 trisomy, is associated with mitochondrial dysfunction leading to the accumulation of damaged mitochondria.
M. Bordi +7 more
semanticscholar +1 more source
NIBV Induces Incomplete Autophagy via AMPK‐TFEB, Causing Kidney Injury in Chicks
Advanced Science, EarlyView.This study reveals that NIBV can inhibit the nuclear translocation of TFEB by suppressing the expression of AMPK, leading to the blockade of autophagolysosomal functions, in turn increasing NIBV replication and triggering severe kidney injury in chicks.
Cheng Huang +10 more
wiley +1 more source
Formation and maturation of the autophagosome
The FASEB Journal, 2013 Autophagy is one of the major degradation pathways in the cell. In autophagy, intracellular components are sequestered by autophagosomes and then degraded upon fusion with lysosomes. Formation of the autophagosome is governed by organized functions of autophagy‐related (Atg) proteins, which were originally identified in yeast.
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REGULATION OF CELLULAR IMMUNE RESPONSE BY NATURALLY OCCURRING PRODUCTS ON HEPATOCELLULAR CARCINOMA [PDF]
Research Journal of Applied Biotechnology, 2016 Hepatocellular carcinoma (HCC) is the most important case of liver cancer disease particularly in Egypt. On the other hand, autophagy plays critical role in cellular immune response in different disease including cancer.
Hany Khalil +2 more
doaj +1 more source
Nature Communications, 2019 The Arabidopsis EH proteins (AtEH1/Pan1 and AtEH2/Pan1) are components of the endocytic TPLATE complex (TPC) which is essential for endocytosis. Both proteins are homologues of the yeast ARP2/3 complex activator, Pan1p.
Pengwei Wang +16 more
semanticscholar +1 more source
Advanced Science, EarlyView.AUTACE is a bifunctional nanoplatform that integrates tumor targeting, immune engagement, and on‐demand KRAS degradation. It targets KRAS/TP53 co‐mutant tumors via TP53‐specific TCRs, elicits antitumor CD8+ T‐cell responses through surface anti‐CD3 antibodies, and uses low‐intensity focused ultrasound (LIFU) to trigger controlled release of the KRAS ...
Luo Li +6 more
wiley +1 more source
SNARE priming is essential for maturation of autophagosomes but not for their formation [PDF]
Proceedings of the National Academy of Sciences, 2017 Significance The contribution of SNARE-mediated membrane fusion to the different stages along the autophagic process is not well understood. In this work we demonstrate that inhibition of SNARE priming leads to impairment of the autophagic flux manifested by the accumulation of mature autophagosomes that do not fuse with the lysosomes.
Abada, Adi +4 more
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