Results 201 to 210 of about 687,627 (397)

Tissue‐Resident Macrophage‐Derived E3 Ligase SMURF2 Restricts Autoimmune Inflammation by Mediating the Degradation of p‐TBK1

Advanced Science, EarlyView.
Dysregulated Tissue resident macrophage (TRMs) link to autoimmune inflammation. SMURF2 mediates Lys‐27 (K27)‐linked ubiquitination of p‐TBK1 and its degradation, which inhibits CSF1R signaling‐triggered TRM proliferation, thereby restraining the autoimmune inflammation.
Xiang An, Jun Li, Lingling Wang, Chengyuan Li, Zhenpeng Jin, Yushi Yao, Minmin Jiang, Wenlong Lin, Xiaojian Wang   +8 more
wiley   +1 more source

PPARγ activation induces autophagy in breast cancer cells

, 2009
Jie Zhou, Wei Zhang, Bing Liang, Mathew C. Casimiro, Diana Whitaker‐Menezes, Min Wang, Michael P. Lisanti, Susan Lanza‐Jacoby, Richard G. Pestell, Chenguang Wang   +9 more
openalex   +1 more source

The benzo[b]fluoranthene in the atmospheric fine particulate matter induces mouse glomerular podocytes injury via inhibition of autophagy

, 2020
Yilin Zhang, Dongwei Liu, Zhangsuo Liu
openalex   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Beclin‐1‐mediated activation of autophagy improves proximal and distal urea cycle disorders

, 2020
Leandro R. Soria, Sonam Gurung, Giulia De Sabbata, Dany Perocheau, Angela De Angelis, Giovanni Bruno, Elena Polishchuk, Debora Paris, Paola Cuomo, Andréa Motta, Michael Orford, Youssef Khalil, Simon Eaton, Philippa B. Mills, Simon N. Waddington, Carmine Settembre, Andrés F. Muro, Julien Baruteau, Nicola Brunetti‐Pierri   +18 more
openalex   +1 more source

The Contribution of Candida albicans Vacuolar ATPase Subunit V ₁ B, Encoded by VMA2 , to Stress Response, Autophagy, and Virulence Is Independent of Environmental pH [PDF]

, 2014
Hallie S. Rane, Stella M. Bernardo, Summer R. Hayek, Jessica Binder, Karlett J. Parra, Samuel A. Lee   +5 more
openalex   +1 more source

Autophagy: Renovation of Cells and Tissues

Cell, 2011
N. Mizushima, M. Komatsu
semanticscholar   +1 more source

Structural and Functional Characterization of EXPO‐Derived Extracellular Vesicles in Plants

Advanced Science, EarlyView.
In this study, 3D electron tomography (ET), cryo‐ET, and immunogold transmission electron microscopy (TEM) are employed to characterize plant extracellular vesicles (EVs) under physiological conditions. EVs are classified into three distinct categories according to their size, content, and molecular‐marker profiles. Furthermore, Exo70E2‐positive medium
Jiayang Gao, Yanbin Li, Shengqi Zhang, Yilin He, Zhiqi Liu, Juan Wang, Jingmin Hua, Jinyu Chen, Junru Zhong, Huan Zhong, Yiji Xia, Yong Cui, Liwen Jiang   +12 more
wiley   +1 more source

FAPα+ Macrophages Orchestrate Immune Evasion in Multiple Myeloma by Dual Regulation of PD‐L1 and T Cell Senescence

Advanced Science, EarlyView.
ABSTRACT Multiple myeloma (MM) is a hematologic malignancy driven by clonal expansion of malignant plasma cells. Despite the long‐term disease control achieved with immunotherapies in some patients, treatment resistance remains a major cause of disease relapse.
Huiyao Gu, Zhenfeng Dai, Xi Huang, Enfan Zhang, Xinyuan Dai, Haoguang Chen, Wen Cao, Jinna Zhang, Yifan Hou, Haimeng Yan, Yang Yang, Li Yang, Yi Li, Wenlong Lin, Zhen Cai, Jingsong He   +15 more
wiley   +1 more source

Identification of therapeutic targets for chronic kidney disease through Mendelian randomization analysis of druggable genes

Scientific Reports
Chronic Kidney Disease (CKD) is a multifaceted and gradually advancing condition characterized by a complex pathogenesis. The current therapeutic options for CKD remain limited in efficacy.
Run-Sen Liang, Jin-Qi Su, Xiang-Qi Wu, Qi Wang, Yong-Mei Cai, Hong-Yong Su, Ji-Xin Tang, Cui-Wei Yao   +7 more
doaj   +1 more source