Results 201 to 210 of about 449,405 (356)

UCP2 Upregulates ACSL3 to Enhance Lipid Droplet Release from Acinar Cells and Modulates the Sirt1/Smad3 Pathway to Promote Macrophage‐to‐Myofibroblast Transition in Chronic Pancreatitis

Advanced Science, EarlyView.
These findings suggest that UCP2 promotes LD formation and release in acinar cells by upregulating ACSL3 expression. This alteration in the local lipid metabolic environment indirectly drives the MMT process. Additionally, UCP2 may regulate the acetylation of Smad3 through Sirt1, enhancing its nuclear activity and activating the TGF‐β/ Smad3 signaling ...
Kunpeng Wang, Lilong Zhang, Beiying Deng, Wanrong Jiang, Tianrui Kuang, Chen Chen, Kailiang Zhao, Qiao Shi, Jun He, Weixing Wang   +9 more
wiley   +1 more source

Inborn errors of canonical autophagy in neurodegenerative diseases. [PDF]

Hum Mol Genet
Freisem D, Hoenigsperger H, Catanese A, Sparrer KMJ.   +3 more
europepmc   +1 more source

Inhibition of Autophagy in Mitotic Animal Cells [PDF]

, 2002
Eeva‐Liisa Eskelinen, Alan R. Prescott, Jennifer Cooper, Saskia M. Brachmann, Lijun Wang, Xiuwen Tang, Jonathan Backer, John M. Lucocq   +7 more
openalex   +1 more source

Gal3‐CaN‐Smurf1 Complex Sequestrates FLCN‐FNIPs to Facilitate TFEB Activation in Response to Endomembrane Damage

Advanced Science, EarlyView.
The schematic diagram illustrates the role of the recruitment of Gal3‐CaN‐Smurf1 complex in maintaining lysosomal membrane homeostasis upon damage. On the one hand, the Gal3‐CaN‐Smurf1 complex sequesters FLCN‐FNIPs to block the activation of RagC, where the active form RagC‐GDP is responsible for TFEB phosphorylation.
Qin Xia, Ziwan Liu, Gaoqing Feng, Wanting Xu, HuaHua Wang, Haihang Su, Jiaqian Li, Dan Liu, Jun Qu, Tonghui Yu, Lei Dong   +10 more
wiley   +1 more source

The emerging roles of autophagy in the homeostasis of lysosome-related organelles. [PDF]

Front Cell Dev Biol
Wang X, Zhang L, Cao X, Zhao Y.
europepmc   +1 more source

Import of a Cytosolic Protein into Lysosomes by Chaperone-mediated Autophagy Depends on Its Folding State

, 2000
Natalia Salvador, Carmen Aguado, Martin Horst, Erwin Knecht   +3 more
openalex   +1 more source

Autophagy lurks around lurcher [PDF]

, 2002
Juan Carlos López
openalex   +1 more source

Autophagy: cellular and molecular mechanisms

Journal of Pathology, 2010
Danielle Glick, S. Barth, K. Macleod
semanticscholar   +1 more source

Revealing Cell‐Free Mitochondrial DNA Breakage Patterns as Novel Biomarkers for Sepsis

Advanced Science, EarlyView.
Uncovering distinct plasma cfmtDNA breakage patterns opens new frontiers for early sepsis detection and prognosis. Unique cleavage hotspots in RNR2 and COX2 regions outperform traditional biomarkers, while mechanistic insights suggest bacterial endonuclease involvement.
Haitang Liao, Ruiyan Ma, Shuai Hao, Xuxin Tan, Xue Zeng, Rui Song, Bing Chen, Zhezhe Cao, Wei Shen, Zhenchun Luo, Jianfeng Huang, He Huang, Liangming Liu, Chenyang Duan   +13 more
wiley   +1 more source

Autophagy in ovary: protective roles, pathological consequences, and unresolved issues. [PDF]

J Ovarian Res
Tang X, Gao X, Wu T, Wang S, Gao Y, Zhang J.   +5 more
europepmc   +1 more source