Results 331 to 340 of about 449,405 (356)
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1996
Autophagy or autophagocytosis are terms given to a membrane-mediated process in eukaryotic cells in which portions of cytoplasm are sequestered within vacuoles and degraded by acid hydrolases that are acquired by fusion with lysosomes. Although vacuoles of this type may be formed under pathologic conditions, autophagy is fundamentally a physiologic ...
MORTIMORE G. E. +3 more
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Autophagy or autophagocytosis are terms given to a membrane-mediated process in eukaryotic cells in which portions of cytoplasm are sequestered within vacuoles and degraded by acid hydrolases that are acquired by fusion with lysosomes. Although vacuoles of this type may be formed under pathologic conditions, autophagy is fundamentally a physiologic ...
MORTIMORE G. E. +3 more
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Current Atherosclerosis Reports, 2008
Autophagy is a catabolic pathway for bulk destruction of long-lived proteins and organelles via lysosomes. Basal autophagy represents a reparative, life-sustaining process, but unrestrained autophagic activity promotes cell death. A growing body of evidence suggests that autophagy occurs in advanced atherosclerotic plaques. Vascular smooth muscle cells,
Martinet, Wim, De Meyer, Guido
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Autophagy is a catabolic pathway for bulk destruction of long-lived proteins and organelles via lysosomes. Basal autophagy represents a reparative, life-sustaining process, but unrestrained autophagic activity promotes cell death. A growing body of evidence suggests that autophagy occurs in advanced atherosclerotic plaques. Vascular smooth muscle cells,
Martinet, Wim, De Meyer, Guido
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Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2012
Autophagy is a process involved in the proteolytic degradation of cellular macromolecules in lysosomes, which requires the activity of proteases, enzymes that hydrolyse peptide bonds and play a critical role in the initiation and execution of autophagy. Importantly, proteases also inhibit autophagy in certain cases.
Boris Zhivotovsky, Vitaliy O. Kaminskyy
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Autophagy is a process involved in the proteolytic degradation of cellular macromolecules in lysosomes, which requires the activity of proteases, enzymes that hydrolyse peptide bonds and play a critical role in the initiation and execution of autophagy. Importantly, proteases also inhibit autophagy in certain cases.
Boris Zhivotovsky, Vitaliy O. Kaminskyy
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Assays for Autophagy II: Mitochondrial Autophagy
2014Autophagy is a bulk degradation process of cytosolic proteins and organelles through the lysosomal/vacuolar machinery. Mitophagy is a type of autophagy that selectively degrades mitochondria. Recent studies have revealed that mitophagy plays an important role in cellular mitochondrial quality control.
Tomotake Kanki, Koji Okamoto
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Autophagy in Huntington disease and huntingtin in autophagy
Trends in Neurosciences, 2015Autophagy is an important biological process that is essential for the removal of damaged organelles and toxic or aggregated proteins by delivering them to the lysosome for degradation. Consequently, autophagy has become a primary target for the treatment of neurodegenerative diseases that involve aggregating proteins.
Dagmar E. Ehrnhoefer +3 more
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2020
The molecular machinery of macroautophagy consists of Atg proteins and supports cytoplasmic constituent degradation in lysosomes as its canonical function, phagosome maturation and exocytosis. These different biological processes contribute to cell intrinsic, innate and adaptive immunity. For the respective immune responses, Atg proteins mediate direct
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The molecular machinery of macroautophagy consists of Atg proteins and supports cytoplasmic constituent degradation in lysosomes as its canonical function, phagosome maturation and exocytosis. These different biological processes contribute to cell intrinsic, innate and adaptive immunity. For the respective immune responses, Atg proteins mediate direct
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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Nature, 2006Taichi Hara +10 more
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Autophagy in metabolic disease and ageing
Nature Reviews Endocrinology, 2021Munehiro Kitada, D. Koya
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2016
Autophagy plays a direct or an indirect role in health and disease. A simplified definition of autophagy is that it is an exceedingly complex process that degrades modified, superfluous (surplus), or damaged cellular macromolecules and whole organelles using hydrolytic enzymes in the lysosomes. It consists of sequential steps of induction of autophagy,
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Autophagy plays a direct or an indirect role in health and disease. A simplified definition of autophagy is that it is an exceedingly complex process that degrades modified, superfluous (surplus), or damaged cellular macromolecules and whole organelles using hydrolytic enzymes in the lysosomes. It consists of sequential steps of induction of autophagy,
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Loss of autophagy in the central nervous system causes neurodegeneration in mice
Nature, 2006M. Komatsu +10 more
semanticscholar +1 more source